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ProteomicsThe effect of elevated copper concentrations on protein production in copper and sulfite tolerant S. cerevisiae
Copper tolerance and sulfite tolerance are two well-studied phenotypic traits of Saccharomyces cerevisiae. The genetic bases of these traits are derived from allelic expansion at the CUP1 locus and reciprocal translocation at the SSU1 locus, respectively. Previous work identified a negative associat...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-22 | PXD037997 | Pride
Sulfite So2 Saccharomyces cerevisiae Copper 
ProteomicsProteomic characterization of the interplay of Staphylococcus aureus and human alveolar epithelial cells during infection - S. aureus proteins
Since infectious diseases caused by Staphylococcus aureus are still a major threat for human health we aimed to gain a detailed understanding of the molecular interplay of pathogen and host upon internalization by proteome analyses. In the present study we infected human alveolar epithelial A549 cel...
ORGANISM(S): Staphylococcus aureus 
2015-08-05 | PXD002384 | Pride
Proteomics Host-pathogen interaction Epithelial cells Internalization Staphylococcus aureus 
ProteomicsThe Amino-Terminal Part of Human Filaggrin-2 is a Component of Cornified Envelopes
Filaggrin-2 (FLG2), a member of the S100-fused type protein family, is a 250 kDa protein mainly expressed in differentiated keratinocytes of the epidermis (Wu et al., 2009; Hsu et al., 2011). Its expression is reduced in atopic dermatitis (Pellerin et al., 2013), and heterozygous non-sense mutations...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD011833 | Pride
Keratinocyte Proteomics Corneocyte Transglutaminase Terminal differentiation Epidermis 
ProteomicsMechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
The S. pombe orthologue of the human PAXT complex, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex which targets cryptic unstable transcripts (CUTs) to the nuclear RNA exosome for degradation. It encompasses the canonical poly(A) polymerase Pla1, responsible for polyadenylation of nascent RNA t...
ORGANISM(S): Fungi Schizosaccharomyces pombe SPK1820 
2022-12-01 | PXD035413 | Pride
Mtrec complex  s. pombe  paxt complex  rna surveilance 
UnknownRandomized international phase III trial of ERCC1 and RRM1 expression-based chemotherapy versus gemcitabine/carboplatin in advanced non-small-cell lung cancer.
Not available
S-EPMC3691357 | biostudies-literature
UnknownStarving infecund widow spiders maintain sexual attractiveness and trade off safety for enhanced prey capture.
Not available
S-EPMC11396026 | biostudies-literature
UnknownNon-targeted metabolomics aids in sex pheromone identification: a proof-of-concept study with the triangulate cobweb spider, Steatoda triangulosa.
Not available
S-EPMC10611747 | biostudies-literature
ProteomicsA new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics.
Pregnancy induces significant physiological changes to support foetal growth, including critical adaptations in pancreatic islets for glucose homeostasis. This study elucidates these adaptations in human islets using immunohistochemistry, with a focus on α- and β-cell metrics, prolactin receptor (PR...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD055852 | Pride
Human Diabetes Pregnancy Pancreas 
UnknownMultimodal and multifunctional signaling? - Web reduction courtship behavior in a North American population of the false black widow spider.
Not available
S-EPMC7043733 | biostudies-literature
ProteomicsMapping of the autophagosomal degradome identifies IL-7Rα as key 1 cargo in proliferating CD4+ T-cells
CD4+ T cells orchestrate both humoral and cytotoxic immune responses. While it is known that CD4+ T cell proliferation relies on autophagy, direct identification of the autophagosomal cargo involved is still missing. Here, we created a transgenic mouse model, which, for the first time, enables us to...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD033733 | Pride
Il-7ra autophagosome degradome 
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