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ProteomicsTowards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics
Objective: Head and neck cancer (HNC) accounts for almost 850,000 new cases per year. Radiotherapy (RT) is used to treat the majority of these patients. A common side-effect of RT-treatment is onset of oral mucositis: a painful irritation and swelling in mouth, which decreases the quality of life an...
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD040398 | Pride
Keratinocytes Interferon response Stat phosphorylation Radiotherapy Mass spectrometry-based proteomics Biomarker Mcm complex 
MetabolomicsSemi‐polar root exudates in natural grassland communities
In the rhizosphere, plants are exposed to a multitude of different biotic and abiotic factors, to which they respond by exuding a wide range of secondary root metabolites. So far, it has been unknown to which degree root exudate composition is species-specific and is affected by land use, the local ...
2018-08-15 | MTBLS671 | MetaboLights
TranscriptomicsMembers of the microRNA-17-92 cluster exhibit a cell intrinsic anti-angiogenic function in endothelial cells
MicroRNAs are endogenously expressed small non-coding RNAs that regulate gene expression on the posttranscriptional level. The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia. Whereas miR-92a was recently identifi...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20745 | biostudies-arrayexpress
TranscriptomicsSca-1 expression defines different developmental stages of mouse PDC that show functional heterogeneity in the endosomal but not lysosomal TLR9 response
Plasmacytoid dendritic cells (PDC) play an important role in innate and adaptive immunity and were shown to be identical to previously described natural IFN-M-NM-1-producing cells (NIP). Here, we describe two functionally distinct PDC subpopulations that are characterized by the differential express...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-42860 | biostudies-arrayexpress
TranscriptomicsMicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-2...
ORGANISM(S): Mus musculus 
2011-10-13 | E-GEOD-32937 | biostudies-arrayexpress
TranscriptomicsMicroRNA-34a regulates cardiac ageing and function
We compared the heart of 6-weeks-old mice (young) with 18-months-old mice (old) hearts of 6 week old and 18 month old mice
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43556 | biostudies-arrayexpress
GenomicsDAC University Hospital Cologne
Data Access Committee EGAC00001000361
EGAC00001000361 | EGA
ProteomicsFunctional analysis of phytoplasma effectors in Vitis vinifera pathogenesis
The aim of the experiment was to identify important protein targets of phytoplasma infection, by isolation of plant proteins, interacting with phytoplasma effectors. Nicotiana benthamiana plants were transformed with YFP (Yellow Fluorescent Protein) tagged phytoplasma effector PoStoSP28, the leaves ...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2023-10-24 | PXD015374 | Pride
Nicotiana benthamiana Phytoplasma effectors. yellow fluorescent protein (yfp) Vitis vinifera Pathogenesis 
ProteomicsProfiling of protein interactions of the circRNA cZNF292 in endothelial cells
Circular RNAs are a class of non-coding RNAs mostly generated by back-splicing RNA transcripts of protein-coding gene loci. In difference to canoncial splicing, back-splicing ligates downstream splice donor site with an upstream splice acceptor generating a covalently closed circular RNA. CircRNAs h...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD029794 | Pride
Affinity purification Endothelial cells Lc-msms Circrna 
TranscriptomicsSTAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence
Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure cases and is characterised by reduced pericyte coverage. While the contributions of other cardiac cell types to HFpEF are well-studied, the role of pericytes remains less understood. Using murine single-nucleus...
ORGANISM(S): Homo sapiens 
2025-04-25 | E-MTAB-15019 | biostudies-arrayexpress
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