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ProteomicsProtein composition of extracellular vesicles isolated from Haloferax volcanii
In order to understand extraceluular vesicle (EV) production in Euryarchaea, and in particular halophilic archaea, we used the model archaeal organism, Haloferax volcanii, to investigate the composition of EVs as well as their capacity to transfer their cargo to other organisms. EVs were isolated in...
ORGANISM(S): Haloferax volcanii DS2 
2024-05-24 | PXD038319 | Pride
Haloarchaea Extracellular vesicles 
TranscriptomicsTranscription profiling of human NIH-3T3 fibroblasts stably expressing the coxsackie-adenovirus receptor (CARI?1)) cells were transduced with adenovirus containing empty vector (AdEmpty) followed by addition of vehicle (DMSO) or transduced with adenovirus encoding either full length HA-tagged PPARg2 or A/B-domain deleted HA-PPARgCDE and treated with rosiglitazoneNIH-3T3 fibroblasts stably expressing the coxsackie-adenovirus receptor (CARI?1)) cells were transduced with adenovirus containing empty vector (AdEmpty) followed by addition of vehicle (DMSO) or transduced with adenovirus encoding either full length HA-tagged PPARg2 or A/B-domain deleted HA-PPARgCDE and treated with rosiglitazone reveals the PPARg2 A/B-domain plays a gene specific role in transactivation and co-factor recruitment
We have previously shown that adenoviral expression of peroxisome proliferator-activated receptors (PPARs) leads to rapid establishment of transcriptionally active complexes and activation of target gene expression within 5-8 h following transduction. Here we have used the adenoviral delivery system...
ORGANISM(S): Mus musculus 
2009-04-04 | E-GEOD-15433 | biostudies-arrayexpress
TranscriptomicsDeletion of hyaluronan synthase 3 inhibits neointimal hyperplasia
Affymetrix Mouse Gene 2.0 ST Gene Expression Microarrays were used to analyze differentially expressed genes after carotid artery ligation. The aim of this experiment was to detect genes regulated in Has3 deficient as compared to wildtype controls that might be involved in neointimal hyperplasia. Ne...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-70410 | biostudies-arrayexpress
ProteomicstRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity
Post-transcriptional modification of tRNAs represents an essential layer of translational regulation critical for bacterial adaptation to environmental changes. Increasing evidence links the tRNA epitranscriptome to pivotal roles in the regulation of gene expression and various cellular processes, i...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2025-08-04 | PXD060249 | Pride
Trna modification Pseudomonas aeruginosa Epitranscriptomics 
ProteomicsMiaA-mediated tRNA modifications couple tryptophan biosynthesis operon attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
tRNA-modifying enzymes are emerging as key regulators of bacterial physiology. MiaA, a tRNA isopentenyltransferase, is well studied in model organisms, but its role in the pathogen Pseudomonas aeruginosa remains unclear. Using LC–MS, nanopore sequencing, and transcriptional, translational and proteo...
ORGANISM(S): Pseudomonas aeruginosa PA14 Bacteria 
2026-09-07 | PXD076088 | Pride
Trna-modifying enzymes Pseudomonas aeruginosa 
TranscriptomicsOncogenic Myc levels activate and repress specific genes to form characteristic expression profiles in human tumors
Myc was depleted in HeLa cells (ATCC CRL-1934) with an shRNA and the resulting expression profile changes mapped via microarrays. This study is the equivalent of E-MTAB-1524 . E-MTAB-1524 has been replaced by E-MTAB-1886.
ORGANISM(S): Homo sapiens 
2014-07-11 | E-MTAB-1886 | biostudies-arrayexpress
GenomicsActivation and repression by oncogenic Myc shapes tumour-specific gene expression profiles
In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downreg...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-44672 | biostudies-arrayexpress
TranscriptomicsGenome-wide maps of chromatin changes uppon contextual fear conditioning in mice (RNA-seq)
The ability to form memories is a prerequisite for an organism’s behavioural adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-74966 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin changes uppon contextual fear conditioning in mice (meDIP-seq)
The ability to form memories is a prerequisite for an organism’s behavioural adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-74965 | biostudies-arrayexpress
UnknownIdentification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Not available
S-EPMC4962376 | biostudies-literature
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