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ProteomicsAnticodon loop remodeling and D-stem shape drive the specific recognition of ANN-decoding tRNAs for t6A modification
N6-threonylcarbamoyladenosine (t6A) is a universal tRNA modification essential for translational fidelity. The modification is installed at position 37 of ANN-decoding tRNAs (N is A, U, G or C) by transfer of a threonylcarbamoyl moiety from a pathway intermediate, catalyzed in bacteria by the TsaBD ...
ORGANISM(S): Escherichia coli 
2026-05-28 | PXD071262 | Pride
Cryo-em Trna Tsab2d2 T6a 
UnknownAn efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function.
Not available
S-EPMC4704475 | biostudies-literature
ProteomicsRefinement of paramagnetic bead–based digestion protocol for automatic sample preparation using an artificial neural network
Despite technological advances in the proteomics field, sample preparation still represents the main bottleneck in mass spectrometry (MS) analysis. Bead-based protein aggregation techniques have recently emerged as an efficient, reproducible, and high-throughput alternative for protein extraction an...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Rattus norvegicus (Rat) 
2024-05-31 | PXD048358 | Pride
Bile Magnetic beads Protein aggregation Sp3 protein digestion Artificial neural network 
UnknownThe lasting legacy of Charles Fisher (1908-1988), pioneering sleep laboratory scientist and sleep medicine psychiatrist.
Not available
S-EPMC11604066 | biostudies-literature
MetabolomicsAtlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Folates participate in the one-carbon metabolism (OCM) cycle, supporting many biochemical pathways. Existing methods to profile folate are limited in the diversity of vitamers they measure and the samples they profile. We present a metabolomics workflow for stable extraction, separation, and meas...

2026-02-10 | MTBLS13484 | MetaboLights
UnknownIdentifying pleiotropic genes in genome-wide association studies from related subjects using the linear mixed model and Fisher combination function.
Not available
S-EPMC5571642 | biostudies-literature
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
GenomicsTargeted resequencing of phenology genes in a diverse panel of barley varieties
We provide raw gene sequences of 174 flowering time regulatory genes and gene othologs across a large barley population (895 barley lines) selected from a collection of landrace, cultivated barley, and research varieties of diverse origin. This set represents the whole variety of cultivated barley l...
ORGANISM(S): Hordeum vulgare subsp. vulgare 
2019-02-15 | E-MTAB-7362 | biostudies-arrayexpress
ProteomicsA helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis to promote parasite chronicity
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of chronic intestinal helminth infection, we identify helminthic glutamate dehydrogenase (heGDH) as an essential factor for parasite chronicity by using antibody mediated neutralization...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD044102 | Pride
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis to promote parasite chronicity 
UnknownThe Founders' 400 and Chicago Perinatal Origins of Disease study protocol: Following a prospective, longitudinal cohort from early pregnancy through two years of postnatal life.
Not available
S-EPMC12478913 | biostudies-literature
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