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MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
TranscriptomicsCell-specific and spatio-temporal controls of the estrogen-responsive trefoil factor (TFF) locus activity.II.
Cell-specific transcriptional regulations exerted by the estrogen (E2) receptor alpha (ER) heavily rely upon timely and spatially coordinated processes. We engaged a comparative analysis of such dynamic molecular events at the TFF locus harbouring a cluster of genes co-regulated by E2, in two distin...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-23850 | biostudies-arrayexpress
TranscriptomicsHouse Dust Mediates Gut Microbiome Lactobacillus johnsonii Enrichment and Immune Defense Against Airway Allergens [Set2]
Exposure to dogs in early infancy has been shown to reduce the risk of childhood allergic disease development and dog-ownership is associated with a distinct house dust microbial exposure. Here we demonstrate, using murine models, that exposure of mice toM-BM- dog-associated house dust protects agai...
ORGANISM(S): Mus musculus 
2013-12-20 | E-GEOD-52907 | biostudies-arrayexpress
TranscriptomicsHouse Dust Mediates Gut Microbiome Lactobacillus johnsonii Enrichment and Immune Defense Against Airway Allergens [Set1]
Exposure to dogs in early infancy has been shown to reduce the risk of childhood allergic disease development and dog-ownership is associated with a distinct house dust microbial exposure. Here we demonstrate, using murine models, that exposure of mice toM-BM- dog-associated house dust protects agai...
ORGANISM(S): dust metagenome 
2013-12-20 | E-GEOD-52906 | biostudies-arrayexpress
ProteomicsProteomic Analysis of a PLK1-Dependent, Cell Cycle Degradation Program
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCFβTrCP. However, the magnitu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046039 | Pride
Degradation Plk1 Cell cycle Ubiquitin 
TranscriptomicsHouse Dust Mediates Gut Microbiome Lactobacillus johnsonii Enrichment and Immune Defense Against Airway Allergens
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-12-20 | E-GEOD-52909 | biostudies-arrayexpress
ProteomicsMammalian proteome changes during oxidative stress and stress of the endoplasmic reticulum
Stress due to protein misfolding in the endoplasmic reticulum affects transcription and translation, RNA and protein degradation. By integrating several large-scale datasets, we quantified transcription, translation, RNA-protein binding events, and protein levels for several thousands of genes in He...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD008575 | Pride
Er stress Translation Proteomics Oxidative stress 
ProteomicsHigh-resolution proteomics of Zika and Dengue serum samples
We used data independent acquisition (DIA) mass spectrometry (MS) to profile ~800 proteinsfrom 122 serum samples Dengue or Zika Trinidadian patients. Two time points were collectedper patient. The DIA MS data were matched against a spectral library generated from high pH/low pH separated pooled seru...
ORGANISM(S): Homo sapiens (Human) 
2021-03-09 | PXD015422 | Pride
Dia Serum Dengue Zika 
TranscriptomicsSmall ncRNA expression-profiling of blood from Hemophilia A patients identifies miR-1246 as a potential regulator of Factor 8 gene
Hemophilia A (HA) is a bleeding disorder caused by deficiency of functional plasma clotting factor VIII (FVIII). In addition to genetic mutations in the gene encoding FVIII (F8), there is evidence that other molecular mechanisms may be involved in the pathobiology of HA. In this study, global small ...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-65581 | biostudies-arrayexpress
ProteomicsN2-methylguanosine modifications on human tRNAs and snRNA U6 are important for colon cancer cell proliferation, protein translation and pre-mRNA splicing
Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an important layer of gene expression regulation through their ability to fine-tune mRNA maturation and transla-tion. Growing evidences support important roles of tRNA/snRNAs modifications and hence the enzymes that install...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD038997 | Pride
Bioid experiment 
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