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TranscriptomicsRNA-seq of human intestinal organoids colonized with E. coli and other immature intestinal tissues
We performed RNA-seq to demonstrate that the epithelium of human pluripotent stem cell-derived human intestinal organoids is globally similar to the immature human epithelium and we utilize HIOs to investigate complex host-microbe interactions in this naive epithelium. RNA was isolated using the mir...
ORGANISM(S): Homo sapiens 
2017-09-01 | E-MTAB-5801 | biostudies-arrayexpress
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsComparison of the nucleotide-resolution, genome-wide, 5'-end maps of the transcriptomes of Escherichia coli K12 strain BW25113 and Streptomyces coelicolor A3(2) strain M145
The differential RNA-seq data contained within this entry is complemented by global RNA-seq. S. coelicolor and E. coli reference strains were grown in batch culture with shaking. The E. coli sample was extracted during mid-exponential growth, while the S. coelicolor sample was extracted at the start...
ORGANISM(S): Escherichia coli BW25113 
2013-05-01 | E-GEOD-46507 | biostudies-arrayexpress
TranscriptomicsComparison of nucleotide-resolution, genome-wide transcriptome maps of Escherichia coli K12 strain BW25113 and Streptomyces coelicolor A3(2) strain M145.
This data contained within this entry was produced as part of a study that included differential RNA-sequencing. S. coelicolor and E. coli reference strains were grown in batch culture with shaking. The E. coli sample was extracted during mid-exponential growth, while the S. coelicolor sample was ex...
ORGANISM(S): Escherichia coli K-12 
2013-04-20 | E-GEOD-46232 | biostudies-arrayexpress
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
TranscriptomicsIGR_PBI_SOCS1_GE_JP
Suppressor of cytokine signaling (SOCS1) is an inducible negative regulator of cytokine signaling. SOCS1 is expressed in normal colonic epithelium and colon adenocarcinomas. However, the levels of SOCS1 decreased during progression of colon adenocarcinomas, the lowest level being found in the more ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-1742 | biostudies-arrayexpress
ProteomicsProteomic Analysis of rattus norvegicus colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea by label-free LC–MS/MS
To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics anal...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD025558 | Pride
Lc-msms Colonic mucosa Rat Acupuncture 
MetabolomicsJasmonate-mediated stomatal closure under elevated CO2 revealed by time-resolved metabolomics
Foliar stomatal movements are critical for regulating plant water loss and gas exchange. Elevated carbon dioxide (CO2) levels are known to induce stomatal closure. However, the current knowledge on CO2 signal transduction in stomatal guard cells is limited. Here we report metabolomic responses of Br...
2017-04-25 | MTBLS312 | MetaboLights
ProteomicsExploration of the nurse shark (Ginglymostoma cirratum) plasma immunoproteome using high-throughput LC-MS/MS
LC-MS/MS proteomics was used to identify immune proteins in the plasma of the nurse shark (Ginglymostoma cirratum), using a de novo multi-tissue transcriptome generated for this species. LC-MS/MS was then used to assess the host response to immunization with human serum albumin (HSA) and Complete Fr...
ORGANISM(S): Ginglymostoma cirratum 
2022-08-12 | PXD032158 | Pride
Nurse shark Plasma Immunoproteome Lc-ms/ms 
ProteomicsThe thylakoid lumen Deg1 protease affects non-photochemical quenching via the levels of violaxanthin de-epoxidase and PsbS
Non-photochemical quenching (NPQ), the dissipation of excess light energy as heat, has been long recognized as a major protective mechanism that minimizes the potential for oxidative damage to photosystem II (PSII) reaction centers. Two major positive contributors to NPQ are the carotenoid zeaxanthi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-06 | PXD046885 | Pride
Arabidopsis thaliana Deg58 protease High-light Proteomics Deg1 protease 
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