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ProteomicsA PEROXO-Tag enables rapid isolation of peroxisomes from human cells
Peroxisomes are metabolic organelles that perform a diverse array of critical functions in human physiology. Traditional isolation methods for peroxisomes can take more than one hour to complete and can be laborious to implement. To address this, we have now extended our prior work on rapid organell...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD018918 | Pride
Human hek-293t Peroxisome 
MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
ProteomicsInteraction of Hsp70 Ssb1 and atypical Hsp70 Ssz1
Our goal was to better understand the interaction between the Hsp70 Ssb1 and the atypical Hsp70 Ssz1, which we had uncovered by in vivo site-specific Bpa crosslinking. Ssz1 having Bpa incorporated was purified and incubated with purified Ssb1 and the J-domain protein Zuo1 during activation of photo ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-26 | PXD024065 | Pride
Yeast Ssb1 Mass spectrometry Photo crosslinking Ssz1 
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
Genomicsmerged_dataset - samples
This dataset contains merged data from the 22 Hodgkin lymphoma and 5 reactive lymph node samples, including count data and cell cluster assignments.
EGAD00001006221 | EGA
Genomicsena-DATASET-BCCA-11-12-2019-18:47:10:446-1110 - samples
Single-cell gene expression was profiled for 22 Hodgkin lymphoma tumors and 5 reactive lymph nodes (2 replicates were performed for RLN-1). Library preparation was performed with the 10x Chromium platform (3' version 2 assay). Sequencing was performed on an Illumina NextSeq. The BAM files were gener...
EGAD00001005739 | EGA
UnknownMeasuring the impact of steroid therapy on health-related quality of life in patients with rheumatic diseases: international development of a glucocorticoid treatment-specific patient-reported outcome measure.
Not available
S-EPMC10629780 | biostudies-literature
GenomicsSingle-cell RNA sequencing of 22 Hodgkin lymphoma tumors and 5 reactive lymph nodes
Hodgkin lymphoma (HL) is characterized by an extensively dominant tumor microenvironment (TME) composed of different types of non-cancerous immune cells with rare malignant cells. Characterization of the cellular components and their spatial relationship is crucial to understanding crosstalk and the...
EGAS00001004085 | EGA
TranscriptomicsDamID from Drosophila CNS with Dam fused FruMA, FruMB, FruMC.
In Drosophila,male courtship behaviour serves as an excellent paradigm to study how innate behaviors are controlled by the nervous system. These behaviors are in large part regulated by the gene fruitless (fru). fru encodes a set of putative transcription factors that promote male sexual behaior by ...
ORGANISM(S): Drosophila melanogaster 
2014-01-16 | E-GEOD-52247 | biostudies-arrayexpress
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