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MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
ProteomicsWhole Cell Proteomics of HSV-1 infected i3Neurones with proteolysis inhibition
Herpes simplex virus 1 (HSV‑1) infections of the central nervous system cause encephalitis and are associated with increased risk of neurodegeneration, yet the molecular consequences of lytic infection in human neurones remain incompletely defined. We mapped the proteomic changes induced by HSV‑1 ac...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2026-10-16 | PXD081186 | Pride
Human Lc-msms Bafilomycin a1 Hsv-1 Neurone Herpes simplex virus 1 Mg132 
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
GenomicsMicroRNAs maintain bivalency in mouse embryonic stem cells [ChIP-seq]
The protein Dicer is required for microRNA (miRNA) biogenesis, and therefore Dicer-deficient cells lack all mature, functional miRNAs. Here we investigated the binding of the PRC2 component Ezh2 in wildtype and Dicer-deficient mouse embryonic stem cells genomewide using ChIP-sequencing analysis. Exa...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-60160 | biostudies-arrayexpress
TranscriptomicsExpression data from wildtype and Dicer-deficient mouse embryonic stem (ES) cells at different stages of the cell cycle.
The protein Dicer is required for microRNA (miRNA) biogenesis. Dicer-deficient cells therefore lack almost all mature, functional miRNAs. We investigated the role of miRNAs in regulation of gene expression in mouse ES cells by analysing gene expression in either wildtype or Dicer-deficient cells gro...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-60096 | biostudies-arrayexpress
UnknownExperiences and Perceptions of Self-Harm in Rural-Dwelling Adults: A Rapid Review of Qualitative Evidence.
Not available
S-EPMC12022502 | biostudies-literature
UnknownDefining the Role of the Fire and Rescue Service in Mental Health Support for Older Adults: A Qualitative Study.
Not available
S-EPMC11411195 | biostudies-literature
UnknownPotentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner.
Not available
S-EPMC4935658 | biostudies-literature
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
ProteomicsProteomics of Dictyostelium discoideum mitochondria
There is a paucity of data regarding what proteins localize to the mitochondria in the social amoeba Dictyostelium discoideum. Therefore, here, we utilized high-throughput tandem mass tag (TMT)-based protein quantitation to identify proteins in the whole-cell lysate, as well as in crude and purified...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2022-06-06 | PXD029101 | Pride
Dictyostelium discoideum Proteomics Tmt Mitochondria purification Lcmsms 
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