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TranscriptomicsDamID from Drosophila CNS with Dam fused FruMA, FruMB, FruMC.
In Drosophila,male courtship behaviour serves as an excellent paradigm to study how innate behaviors are controlled by the nervous system. These behaviors are in large part regulated by the gene fruitless (fru). fru encodes a set of putative transcription factors that promote male sexual behaior by ...
ORGANISM(S): Drosophila melanogaster 
2014-01-16 | E-GEOD-52247 | biostudies-arrayexpress
TranscriptomicsAlterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at least in part, by ethanol-ev...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73018 | biostudies-arrayexpress
ProteomicsEPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
EPLIN, an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain largely unknown and could explain these opposing views. We observed distinct EPLIN isoform localization in breast cancer cells; EPLINα is r...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD052819 | Pride
Bioid Breast cancer Lc-msms Human 
TranscriptomicsAge-related changes in microRNA levels in serum (mRNA)
Age-related changes in microRNA levels in serum 20 nM biotinylated miRIDIAN miR-1248 mimic (Thermo Scientific) or a negative control, biotinylated miRIDIAN C. elegans miR-67 (here named Con-miR) using Lipofectamine 2000. Forty eight hours post transfection, total RNA was isolated using the mirVana...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-51309 | biostudies-arrayexpress
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [differentiation data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40956 | biostudies-arrayexpress
ProteomicsCLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
CLPB is a mitochondrial intermembrane space AAA+ domain–containing disaggregase. CLPB mutations are associated with 3-methylglutaconic aciduria and neutropenia; however, the molecular mechanism underscoring disease and the contribution of CLPB substrates to disease pathology remains unknown. Interac...
ORGANISM(S): Homo sapiens (Human) 
2024-01-18 | PXD042313 | Pride
Disaggregase Protein transport Mitochondria Protein quality control Mitochondrial disease 
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
ProteomicsConsumption of traditional Sardinian fermented milk promotes changes in the rat gut microbiota composition and functions
Introduction: Fermented milk products are part of the staple diet for many Mediterranean populations. Most of these traditional foods are enriched with lactobacilli and other lactic acid bacteria and metabolites resulting from lactose fermentation. There is currently very little scientific knowledge...
ORGANISM(S): rat gut metagenome Rattus norvegicus (Rat) 
2025-09-29 | PXD054645 | Pride
Prevotella Metagenomics Propanoate metabolism Fermented milk Metaproteomics 
ProteomicsGenomic studies controvert the existence of the CUX1 p75 isoform
CUX1, a homeodomain-containing transcription factor, is recurrently deleted or mutated in multiple tumor types. In myeloid neoplasms, CUX1 deletion or mutation carries a poor prognosis. We have previously established that CUX1 functions as a tumor suppressor in hematopoietic cells across multiple or...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027527 | Pride
Q-exactive Human Cux1 Kg-1 cell line 
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