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MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
UnknownRole of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group.
Not available
S-EPMC5015423 | biostudies-literature
ProteomicsEtomoxir: A Promiscuous Fatty Acid Mimetic Chemoproteomic Probe
Etomoxir has been used for decades as a popular small molecule inhibitor of Carnitine Palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid b-oxidation. To test the specificity of etomoxir, we generated click chemistry enabled reagents to label etomoxir binding proteins in situ. Etomoxir b...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-04 | PXD051969 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsEtomoxir as a Promiscuous Chemoproteomic Probe.
Primary hepatocytes from WT or Pex5KO mouse livers were treated with 100uM clickable etomoxir analogues and the proteins bound to etomoxir were pulled down and identified. The small molecule inhibitor etomoxir has been used for many years as a specific inhibitor of Cpt1 but these data show that etom...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD045866 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsRab30 regulates lipid homeostasis in the hepatocyte during fasting
In order to facilitate inter-tissue communication and exchange of proteins, lipoproteins, and metabolites with the circulation, hepatocytes have an intricate and efficient intracellular trafficking system regulated by small Rab GTPases. Rab30, a putative Golgi-localized Rab GTPase, is induced in th...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-12 | PXD044528 | Pride
Lipoprotein Lipid metabolism Triglycerides Beta oxidation Vesicle transport Ppara Golgi apparatus Small gtpase 
ProteomicsCircadian Rhythms in Cyanobacterial Protein Condensation
Circadian rhythms are endogenously generated daily cycles in physiology that are closely tied to metabolism and can be found in all kingdoms of life. In cyanobacteria, energy storage through glycogen metabolism is highly rhythmic, but the underlying mechanisms remain unclear. Here we find that the g...
ORGANISM(S): Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) Bacteria 
2026-05-25 | PXD074299 | Pride
Circadian Cyanobacteria 
UnknownUS Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose-Positron Emission Tomography Imaging: Southwest Oncology Group S0816.
Not available
S-EPMC4966513 | biostudies-literature
ProteomicsRab30 regulates lipid homeostasis in the hepatocyte during fasting
In order to facilitate inter-tissue communication and exchange of proteins, lipoproteins, and metabolites with the circulation, hepatocytes have an intricate and efficient intracellular trafficking system regulated by small Rab GTPases. Rab30, a putative Golgi-localized Rab GTPase, is induced in th...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-04 | PXD050376 | Pride
Rab gtpases  liver  ppara  lipid metabolism  fasting 
MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
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