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TranscriptomicsRNA-SEQ of WT and iMSN-D2RKO Parkinson's mice model treated with L-dopa
We analyzed the RNA expression profiles of Parkinson's model (6-hydroxydopamine lesion, 6-OHDA) mice in two different genotypes, WT and iMSN-D2RKO mice. Mutant iMSN-D2RKO mice were generated by mating D2Rflox/flox males with D2Rflox/flox females carrying the CRE under the control of the D1 receptor ...
ORGANISM(S): Mus musculus 
2023-06-06 | E-MTAB-11848 | biostudies-arrayexpress
MetabolomicsMulti-omics analysis of thermogenic lipolysis in brown adipocytes

The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are conside...

2025-11-12 | MTBLS12307 | MetaboLights
ProteomicsMass spectrometric ITEM-TWO analyses of interactions between human cardiac Troponin T (hcTnT) peptides and the M7 or the M11.7 antiTnT antibodies.
Molecular characterization of antibodies M7, and M11.7, as well as the antiTNF alpha antibody in addition to the synthetic peptides P11-P17 and P21-P32. The M7 and M11.7 anti-human cardiac Troponin T (antihcTnT) antibodies from Roche Diagnostics Deutschland GmbH (Mannheim, Germany) and the antiTNF a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD058812 | Pride
Item-two Troponin t Offline nanoesi-ms 
ProteomicsProtein (elafin) cleavage by the main Lactobacillus spp encountered in the female gynecological tract
Mass spectrometry analyses for determining whether 13C615N2-labeled lysines contained in the elafin (innate peptide highly expressed in lower female genital tract and down-regulated in case of HPV infection) were found in the amino acid sequence of some proteins of Lactobacilli, supporting the funda...
ORGANISM(S): Lactobacillus 
2022-04-04 | PXD022113 | Pride
Elafin Lactobacillus 
Proteomics4-Oxo-2-nonenal Adductions in Cells
4-Oxo-2-nonenal (ONE) derived from lipid peroxidation modifies nucleophiles and transduces redox signaling by its reactions with proteins. However, the molecular interactions between ONE and complex proteomes and their dynamics in situ remain largely unknown. Here we de-scribe a quantitative chemopr...
ORGANISM(S): Homo sapiens (Human) 
2017-08-25 | PXD007149 | Pride
4-oxo-2-nonenal 
TranscriptomicsTranscription profiling of human macrophages from ankylosing spondylitis patients reveals interferon-gamma dysregulation
OBJECTIVE: To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern. METHODS: Macrophages were derived from the peripheral blood of 8 AS patients (median disease duration 13 years [range <1-43 yea...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11886 | biostudies-arrayexpress
ProteomicsChemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells
4-Oxo-2-nonenal (ONE) derived from lipid peroxidation modifies nucleophiles and transduces redox signaling by its reactions with proteins. However, the molecular interactions between ONE and complex proteomes and their dynamics in situ remain largely unknown. Here we de-scribe a quantitative chemopr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD006680 | Pride
Chemoproteomics Click chemistry 4-oxo-2-nonenal 
TranscriptomicsTranscriptional characterization of Human Lung Organoids (HLOs) using RNAseq
Human lung organoids (HLOs) were derived from human embryonic stem cell line H9 NIH registry #0062. Sequencing of HLOs was performed by the UM DNA Sequencing Core, using Illumina Hi-Seq platform and single-end 50 bp reads. The UM Bioinformatics Core downloaded the reads files from the Sequencing Cor...
ORGANISM(S): Homo sapiens 
2015-03-09 | E-MTAB-3339 | biostudies-arrayexpress
ProteomicsRegulation of the stress proteome by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation prevents cytotoxic stress but the mechanisms are diffuse. We investigated changes in the proteom...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-06 | PXD025396 | Pride
Autophagy Erad Phospholipid Programmed cell death Upr Stress signaling Monounsaturated fatty acid Mouse fibroblast 
ProteomicsRNA to rule them all: Critical steps in Lassa virus ribonucleoparticle assembly and recruitment
Lassa virus is a negative-strand RNA virus with only four structural proteins that causes periodic outbreaks in West Africa. The nucleoprotein (NP) encapsidates the viral genome, forming the ribonucleoparticles together with the viral RNA and the L protein, which have to be continuously restructured...
ORGANISM(S): Lassa mammarenavirus 
2023-12-18 | PXD040186 | Pride
Native ms Lassa virus 
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