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HIM-17 has been implicated in the regulation of DNA double-strand break (DSB) formation during meiosis in C. elegans. In a study assessing various accessory factors involved in programmed meiotic DSB formation we show data identifying protein interactions with HIM-17 obtained by assessing HIM-17-GFP...
ORGANISM(S): Caenorhabditis elegans 
2026-01-28 | PXD057629 | Pride
Cigarette smoking causes serious diseases, including lung cancer, heart disease, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine containing products may reduce disease risks among those unabl...
ORGANISM(S): Mus musculus 
TET genes have been characterized as tumor suppressors because their expression levels are reduced in many human cancers including lymphoma, prostate, and pancreas, and TET2 gene mutations are common in hematological cancers. In contrast, TET1 was recently reported to be overexpressed in triple nega...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD066092 | Pride
The Canarypox/gp120/Alum vaccines decreased the risk of HIV acquisition in humans. We demonstrate here the efficacy of this vaccine regimen also in the SIVmac251 macaque model when we used the alum but not the MF59 adjuvant. Analysis of innate and adaptive cell responses, envelope antibodies Fc prof...
ORGANISM(S): Macaca mulatta 
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
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