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UnknownMDA-9/syntenin is a key regulator of glioma pathogenesis.
Not available
S-EPMC3870820 | biostudies-literature
TranscriptomicsAnalysis of global changes in gene expression induced by human polynucleotide phosphorylase (hPNPaseold-35)
Human Polynucleotide Phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3’?5’ exoribonuclease implicated in the regulation of numerous physiological processes like maintenance of mitochondrial homeostasis, mtRNA import and aging-associated inflammation. From an RNase perspective, little is...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53604 | biostudies-arrayexpress
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
TranscriptomicsRNA-seq of chemically reset human naive pluripotent stem cells
A simple method is presented to reset human pluripotent cells to a naive state via transient histone deacetylase inhibition and maintenance in chemically-defined naive stem cell culture media. Cells can be reset without transgenes and expanded continuously either on feeders or alternative substrates...
ORGANISM(S): Homo sapiens 
2017-08-07 | E-MTAB-5674 | biostudies-arrayexpress
TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
MetabolomicsImproving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry
Untargeted metabolomics aims at obtaining quantitative information on the highest possible number of low-molecular biomolecules present in a biological sample. Rather small changes in mass spectrometric spectrum acquisition parameters may have a significant influence on the detectabilities of metabo...
2016-06-09 | MTBLS233 | MetaboLights
TranscriptomicsTranscriptomic Analysis of Rat Brain Following Exposure to the Organophosphonate Anticholinesterase Sarin
Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasures to nerve agent intoxication increase survival if administered within a short period of time following exposure but...
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-GEOD-28435 | biostudies-arrayexpress
TranscriptomicsA novel aCGH method for non-model organisms for assessing genomes and de-novo transcriptome sequencing reads
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2014-05-19 | E-GEOD-52122 | biostudies-arrayexpress
TranscriptomicsPatterns of gene expression associated with recovery and injury in heat-stressed rats
Background: The in vivo gene response associated with hyperthermia and subsequent return to homeostasis or development of heat illness is poorly understood. Early activation of gene networks in the heat stress response is likely to lead to the systemic inflammation, multi-organ functional impairment...
ORGANISM(S): Rattus norvegicus 
2015-01-14 | E-GEOD-56740 | biostudies-arrayexpress
GenomicsGenomic targets sites of the Candida glabrata transcription factor Pdr1
Pdr1 is the major regulator of azole resistance in the fungal pathogen Candida glabrata. Earlier experiments demonstrated that expression of Pdr1 itself is increased when cells lose their mitochondrial genome (rho0). Here we use chromatin immunoprecipitation coupled with highthroughput sequencing ...
ORGANISM(S): Candida glabrata CBS 138 
2014-09-12 | E-GEOD-59839 | biostudies-arrayexpress
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