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MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
MetabolomicsMetabolomic analysis reveals a differential adaptation process of the larval stages of Anisakis simplex to the host environment

Anisakis simplex are parasitic nematodes that cause anisakiasis. The possibility of infection with this parasite is through consumption of raw or undercooked fish products. A. simplex infections are often misdiagnosed, especially in subclinical cases that do not present with typ...

2023-07-08 | MTBLS6458 | MetaboLights
UnknownA multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1.
Not available
S-EPMC5395076 | biostudies-literature
ProteomicsCharacterisation of urinary WFDC12 in nocturnal basal primates, mouse lemurs (Microcebus spp.), C4PR_LIV
Mouse lemurs are basal primates that rely on chemo- and acoustic signalling for social interactions in their dispersed social systems. We examined the urinary protein content of two mouse lemurs species, within and outside the breeding season, to assess candidates used in species discrimination, re...
ORGANISM(S): Microcebus murinus 
2017-02-13 | PXD005196 | Pride
Urine Whey acidic protein Mass spectrometry Wfdc12 protein Microcebus lehilahytsara Microcebus murinus Reproduction 
ProteomicsStrategies to enhance the extraction of electrophoretically separated proteins from polyacrylamide gels and their application to mass spectrometry analyses (C4PR_LIV)
Polyacrylamide gel electrophoresis (PAGE) is a powerful technique for separating proteins extracted from complex biological samples. Unfortunately, the difficulty of recovering intact proteins in high yield from polyacrylamide matrices often limits further analyses. We discovered that staining prote...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) Drosophila melanogaster (Fruit fly) 
2020-07-13 | PXD010592 | Pride
Protein extraction Sds page 
MetabolomicsRapid identification of species, sex and maturity by mass spectrometric analysis of animal faeces

BACKGROUND: We describe a new approach to the recovery of information from faecal samples, based on the analysis of the molecular signature generated by rapid evaporative ionisation mass spectrometry (REIMS).

RESULTS: Faecal pellets from five different r...

2022-02-03 | MTBLS1095 | MetaboLights
UnknownInflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration.
Not available
S-EPMC9265516 | biostudies-literature
ProteomicsSynthetic biology meets proteomics: Construction of à la carte QconCATs for absolute protein quantification C4PR_LIV
We report a new approach to the assembly and construction of QconCATs, quantitative concatamers for proteomic applications that yield stoichiometric quantities of sets of stable isotope-labelled internal standards. The new approach is based on synthetic biology precepts of biobricks, making use of ...
ORGANISM(S): Escherichia coli 
2021-11-15 | PXD027521 | Pride
Synthetic biology Qconcat Quantitative proteomics Loop assembly 
TranscriptomicsSingle-base resolution DNA methylomes of soybean recombinant inbred lines reveals heritability patterns of natural methylation variants (RNA-seq)
Microbe associated molecular pattern (MAMP)-triggered immunity (MTI) is an important component of the plant innate immunity response to invading pathogens. Although several MTI responses can be measured in different plant species, their magnitude is likely plant-species specific and even cultivar sp...
ORGANISM(S): Glycine max 
2014-01-08 | E-GEOD-43463 | biostudies-arrayexpress
ProteomicsGlareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus, C4PR_LIV
The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrome...
ORGANISM(S): Myodes glareolus (Bank vole) (Clethrionomys glareolus) 
2017-09-13 | PXD006645 | Pride
Primary sequence Metabolic labelling Obp Mass spectrometry Lipocalin Bank vole Glareosin Myodes glareoulus Odorant binding protein 
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