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MetabolomicsGlycerophospholipid remodeling is critical for orthoflavivirus infection

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights
GenomicsSingle cell transcriptional dynamics of flavivirus infection
Single cell transcriptional dynamics of flavivirus infection
PRJNA433871 | ENA
GenomicsOligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection
Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection
PRJNA1010117 | ENA
GenomicsTMEM41B is a pan-flavivirus host factor
TMEM41B is a pan-flavivirus host factor
PRJNA680347 | ENA
ProteomicsThe flavivirus protein NS4B recruits the cis-Golgi protein ACBD3 to modify ER-Golgi trafficking for virion release
Flavivirus infection involves extensive remodeling of the endoplasmic reticulum (ER), which is key to both the replication of the viral RNA genome as well as the assembly and release of new virions. Yet, little is known about how viral proteins and host factors cooperatively facilitate such a vast t...
ORGANISM(S): Homo sapiens (Human) 
2025-03-31 | PXD051173 | Pride
Acbd3 Ns4b Replication organelles Flavivirus Er exit sites Orthoflavivirus Host-pathogen interaction Eres-golgi contact 
TranscriptomicsAnalysis of the Aedes aegypti transcriptome during flavivirus infection
Microarray analysis on days 1, 2 and 7 post-infection with dengue, yellow fever and West Nile virus in Aedes aegypti Rockefeller strain mosquitoes RNA was purified and hybridized with Nimblegen X4 microarray chips using 81-mer probes designed from 18,000 open reading frames (ORF) found in the Ae. ae...
ORGANISM(S): Aedes aegypti 
2013-03-31 | E-GEOD-28208 | biostudies-arrayexpress
UnknownTranscriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In Vitro.
Not available
S-EPMC11359927 | biostudies-literature
OtherTMEM41B is a pan-flavivirus host factor
Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host factors required for flavivirus infection we performed full-genome loss of function CRISPR-Cas9 screens. Based on these ...
ORGANISM(S): synthetic construct Homo sapiens 
2020-11-24 | GSE162040 | GEO
ProteomicsMembrane tethering by the host ER-resident GTPase Atlastin-2 is critical for flavivirus replication
Flaviviruses (genus Orthoflavivirus) are arthropod-borne viruses which cause approximately 400 million annual global infections in humans. As obligate intracellular pathogens, flaviviruses must co-opt cellular machinery to facilitate their infection and spread. Notably, all flaviviruses replicate in...
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD068694 | Pride
Atl2 Orthoflavivirus Er remodeling 
TranscriptomicsOligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection
In order to recover from infection, organisms must balance robust immune responses to pathogens with the tolerance of immune-mediated pathology. This balance is particularly critical within the central nervous system, whose complex architecture, essential function, and limited capacity for self-rene...
ORGANISM(S): Mus musculus 
2023-11-08 | GSE241804 | GEO
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