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ProteomicsIdentify the host factors interacting with ZIKV NS4B
To identify the host factors involved in NS4B-induced PD-L1 upregulation, we conducted mass spectrometric analysis to identify potential binding partners of NS4B.
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD062250 | Pride
Zikv Ns4b Binding proteins 
ProteomicsA genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication (NS4B Effectome - Global Proteome)
Orthoflavivirus infections represent an increasing public health burden, with several members of the genus emerging or re-emerging globally. Despite the availability of few vaccines, no antiviral drugs are currently licensed for the treatment of orthoflavivirus infections. Several pre-clinical studi...
ORGANISM(S): Homo sapiens (Human) Orthoflavivirus 
2026-03-10 | PXD063404 | Pride
ProteomicsMechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688
Dengue, caused by the dengue virus (DENV), presents a significant public health challenge with limited effective treatments. NITD-688 is a potent pan-serotype DENV inhibitor currently in Phase II clinical trials. However, its mechanism of action is not fully understood. Here, we present the molecula...
ORGANISM(S): Homo sapiens (Human) Dengue virus 
2025-10-06 | PXD053801 | Pride
Ns3 Jnj-1802 Ns4b Viral replication Antiviral Denv Flavivirus Nitd-688 
ProteomicsA genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication (NS4Bome)
Orthoflavivirus infections represent an increasing public health burden, with several members of the genus emerging or re-emerging globally. Despite the availability of few vaccines, no antiviral drugs are currently licensed for the treatment of orthoflavivirus infections. Several pre-clinical studi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD063343 | Pride
TranscriptomicsCharacterization of mutations in West Nile virus NS4B protein identifies proline residue 54 as a determinant of attenuation
The flavivirus genus has conserved NS4B residues at P54, L56, and W103. We sought to determine both in vitro and in vivo which mutations displayed attenuated characteristics for use as potential vaccine candidates.
ORGANISM(S): Yellow fever virus 
2023-10-06 | E-MTAB-9408 | biostudies-arrayexpress
ProteomicsProteome of ZIKV-infected and NS4B-transduced hNPC (H/PF/2013)
To investigate the effects of ZIKV infection or ZIKV-NS4B-transduction on the global proteome scale at early stages of hNPC differentiation into neurons, hNPC cells were infected with ZIKV (Asian strain: H/PF/2013; MOI=0.01) or transduced with ZIKV-NS4B or HCV-NS4B and one day later cells were eithe...
ORGANISM(S): Homo sapiens (Human) Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 
2018-09-03 | PXD009557 | Pride
Zikv Differentiation Hnpc Proteome 
GenomicsCharacterization of mutations in West Nile virus NS4B protein identifies proline residue 54 as a determinant of attenuation
Characterization of mutations in West Nile virus NS4B protein identifies proline residue 54 as a determinant of attenuation
PRJEB39655 | ENA
GenomicsATAC-seq analysis of human CD8 T cells specific for the NS4B-214 epitope in the Yellow fever vaccine YFV-17D strain
ATAC-seq analysis of human CD8 T cells specific for the NS4B-214 epitope in the Yellow fever vaccine YFV-17D strain
ORGANISM(S): Homo sapiens 
2017-12-13 | GSE101609 | GEO
UnknownCharacterization of dengue virus NS4A and NS4B protein interaction.
Not available
S-EPMC4403404 | biostudies-literature
UnknownRab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Not available
S-EPMC5550665 | biostudies-literature
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