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Targeted proteomic mass spectrometry is emerging as a salient clinical diagnostic tool to track protein biomarkers. Yet, its strong analytical properties have not been exploited in the diagnosis and typing of flavivirus. Here, we report the development of a highly sensitive and specific single-shot ...
ORGANISM(S): Flavivirus 
2019-03-25 | PXD006922 | Pride
TMEM41B is a pan-flavivirus host factor
Flavivirus Capsid Proteins Facilitate Genome Compaction and Packaging
Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes
Flavivirus infection involves extensive remodeling of the endoplasmic reticulum (ER), which is key to both the replication of the viral RNA genome as well as the assembly and release of new virions. Yet, little is known about how viral proteins and host factors cooperatively facilitate such a vast t...
ORGANISM(S): Homo sapiens (Human) 
2025-03-31 | PXD051173 | Pride
Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host factors required for flavivirus infection we performed full-genome loss of function CRISPR-Cas9 screens. Based on these ...
ORGANISM(S): Homo sapiens synthetic construct 
2020-11-24 | GSE162040 | GEO
A volatile from skin microbiota of flavivirus-infected host promotes mosquito attractiveness
Mosquito-borne flaviviruses maintain life cycles in mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether and how flavivirus induces and antagonizes RNAi-mediated antiviral immunity in mammals remains unknown. Here we sh...
ORGANISM(S): Aedes aegypti Homo sapiens 
2020-02-24 | GSE133284 | GEO
Membrane tethering by the host ER-resident GTPase Atlastin-2 is critical for flavivirus replication
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