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TranscriptomicsTranscriptome analysis of compound-treated cells
Huh7.5.1 cells were incubated for 48 h with LY-411575, JNJ-1802, NITD-688, and NITD-008 at their respective EC90 concentrations against DENV: 10 nM, 0.1 nM, 7 nM, and 1.3 μM. Cells treated with DMSO served as controls. Three replicates for each treatment.Total RNA was extracted using the RNeasy Mini...
ORGANISM(S): Homo sapiens 
2024-12-29 | E-MTAB-14694 | biostudies-arrayexpress
UnknownModelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.
Not available
S-EPMC10699615 | biostudies-literature
UnknownSafety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.
Not available
S-EPMC10506772 | biostudies-literature
ProteomicsMechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688
Dengue, caused by the dengue virus (DENV), presents a significant public health challenge with limited effective treatments. NITD-688 is a potent pan-serotype DENV inhibitor currently in Phase II clinical trials. However, its mechanism of action is not fully understood. Here, we present the molecula...
ORGANISM(S): Homo sapiens (Human) Dengue virus 
2025-10-06 | PXD053801 | Pride
Ns3 Jnj-1802 Ns4b Viral replication Antiviral Denv Flavivirus Nitd-688 
UnknownBlocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Not available
S-EPMC10033419 | biostudies-literature
UnknownQSPR graph model to explore physicochemical properties of potential antiviral drugs of dengue disease through novel coloring-based topological indices.
Not available
S-EPMC12400515 | biostudies-literature
GenomicsTranscriptome analysis of compound-treated cells
Transcriptome analysis of compound-treated cells
PRJEB83388 | ENA
UnknownMechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688.
Not available
S-EPMC12002330 | biostudies-literature
UnknownTrends and insights in dengue virus research globally: a bibliometric analysis (1995-2023).
Not available
S-EPMC11370300 | biostudies-literature
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