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ProteomicsQuantification of proteins in the endothelial cell-pericyte interface with and without treatment with 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP)
Goal of the study was to identify (using proteomics) the consequences of the lipocine 19,20-DHDP on the proteins enriched in the junctions between endothelial cells and pericytes.
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD049131 | Pride
Lc-ms/ms Cell-cell junctions Endothelial cells 20-dhdp Pericytes 19 
ProteomicsConsequences of sEH deletion in the polyoma middle T (PyMT) breast cancer tumor proteome
The aim of this investigation was to study the consequences of interfering with soluble epoxide hydrolase (sEH) expression on tumor growth and metastasis in genetically modified animals that spontaneously generate tumors without the exogenous application of high concentrations of epoxide mediators o...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-14 | PXD026214 | Pride
Breast cancer Macrophage Lymphangiogenesis Lc-msms Metastasis 
ProteomicsIdentification of NOS3 interacting proteins
The endothelial nitric oxide (NO) synthase (eNOS, or NOS3) can be activated in response to fluid shear stress and numerous agonists via cellular events such as increased intracellular Ca2+, interaction with substrate, co-factors as well as adaptor and regulatory proteins, protein phosphorylation and...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013755 | Pride
Vascular biology Proteome Lc-msms Enos 
ProteomicsConsequences of Cyp2c44 deletion on proteome of the microsomal fraction of primary polyoma middle T (PyMT) tumors
Here we compared the proteomes of microsomal fractions from primary tumors isolated from PyMT mice versus PyMTxCyp2c44-/- mice.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-03 | PXD017303 | Pride
Breast cancer Macrophage Wdfy1 Lymphangiogenesis Lc-msms Metastasis 
ProteomicsConsequences of Cyp2c44 deletion in the polyoma middle T (PyMT) breast cancer tumor proteome
Comparison of the proteome of intact primary breast cancer tumors from PyMT mice versus PyMTxCyp2c44-/- mice.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-03 | PXD017336 | Pride
Breast cancer Macrophage Wdfy1 Lymphangiogenesis Lc-msms Metastasis 
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