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UnknownImatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Not available
S-EPMC4878082 | biostudies-literature
ProteomicsHuman cytomegalovirus protein pUL36: a dual cell death pathway inhibitor
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of intrinsic, innate and adaptive viral immune evasion. Here, we employ multiplexed tandem mass tag-based proteomics to characterise host proteins targeted for degradation late during HCMV infection. This approach revealed th...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2020-07-10 | PXD017279 | Pride
Human cytomegalovirus  cell death  necroptosis  host-pathogen interaction  quantitative proteomics  protein degradation  proteasome  mlkl 
ProteomicsHCMV US2 co-opts TRC8 to degrade the ER-resident protein LMAN2L
The human cytomegalovirus (HCMV) pUS2 glycoprotein exploits the host’s endoplasmic reticulum (ER)-associated degradation (ERAD) pathway to degrade MHC class I and prevent antigen presentation. Beyond MHC class I, pUS2 has been shown to target a range of cellular proteins for degradation, preventing ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050878 | Pride
Cytomegalovirus Proteomics Protein trafficking Protein degradation Plasma membrane 
ProteomicsSelective modulation of cell surface proteins during vaccinia infection: a resource for identifying viral immune evasion strategies
The interaction between immune cells and virus-infected targets involves multiple plasma membrane (PM) proteins. A systematic study of PM protein modulation by vaccinia virus (VACV), the paradigm of host regulation, has the potential to reveal not only novel viral immune evasion mechanisms, but also...
ORGANISM(S): Homo sapiens (Human) Vaccinia virus WR Vaccinia virus 
2022-06-01 | PXD033407 | Pride
Vaccinia virus  plasma membrane  immune evasion  host-pathogen interaction 
ProteomicsHuman cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate and adaptive immunity. We have employed two novel, orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins downregulated by viral factors e...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2022-02-22 | PXD026785 | Pride
Human cytomegalovirus  restriction factor  innate immunity  immune evasion  host-pathogen interaction  schlafen 
UnknownHigh-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.
Not available
S-EPMC10425737 | biostudies-literature
ProteomicsProteomic analysis of circulating immune cells identifies novel cellular phenotypes associated with COVID-19 severity
Certain serum proteins, including CRP and D-dimer, have prognostic value in patients with SARS-CoV-2 infection. Nonetheless, these factors are non-specific, and provide limited mechanistic insight into the peripheral blood mononuclear cell (PBMC) populations which drive the pathogenesis of severe CO...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD040703 | Pride
Covid-19 Pbmc Cell surface Sars-cov-2 Plasma membrane Phenotype Biomarker 
UnknownCost-Effectiveness of Treatments after Closed Extraarticular Distal Radius Fractures in Older Adults from the WRIST Clinical Trial.
Not available
S-EPMC7855198 | biostudies-literature
UnknownRemote triage incorporating symptom-based risk stratification for suspected head and neck cancer referrals: A prospective population-based study.
Not available
S-EPMC9291313 | biostudies-literature
UnknownIrbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial.
Not available
S-EPMC6934233 | biostudies-literature
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