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ProteomicsLRP6-BirA proximity labelling proteomics comparing wildtype and AP2 binding motif mutant (YYYF) LRP6 in FlpIn T-REx cells
Here we generated tetracycline inducible LRP6-BirA fusion lines in T-REx FlpIn cell lines for BioID proximity labelling proteomics experiments. We compare wt and mutant (YYYF>A mutant; mutates AP2 binding motifs to alanine) LRP6 binding partners following 12hrs Biotin labelling and Wnt3a treatment.
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD054245 | Pride
Wnt Lrp6 Flpin hek293t Bioid 
ProteomicsProteome of HEK293T cells upon P2YR6 overexpression
Defense against virus infections relies on rapid and massive engagement of cellular proteins with antiviral properties. Germline-encoded pattern recognition receptors (PRRs) sense the presence of pathogens and initiate a signaling cascade leading to the induction of antiviral cytokines, including ty...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012277 | Pride
P2yr6 Label-free quantification Lfq Qexactive 
UnknownPhosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2.
Not available
S-EPMC7212651 | biostudies-literature
ProteomicsPhosphoproteomic Characterization of Signaling Networks Resulting from Activation of Chemokine Receptor CCR2
Leukocyte recruitment, a universal feature of tissue inflammation, is regulated by the interactions of chemokines with their G protein-coupled receptors. Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CCL2, plays a central role in recruitment of monocytes in...
ORGANISM(S): Homo sapiens (Human) 
2020-04-08 | PXD015845 | Pride
Ccr2 Dia Phosphoproteomics Signalling 
ProteomicsHs_HEK293_2012_SILAC_Phospho_2_OrbiElite
Human HEK293T, Parental FlpIN T-Rex293, PKD1 kinase dead cells, silac, replicate 2.1
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe004085 | PeptideAtlas
ProteomicsHs_HEK293_2012_SILAC_Phospho_3_OrbiElite
Human HEK293T, Parental FlpIN T-Rex293, PKD1 kinase dead cells, silac, replicate 3.1
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe004070 | PeptideAtlas
ProteomicsHs_HEK293_2012_SILAC_Phospho_2_OrbiXL
Human HEK293T, Parental FlpIN T-Rex293, PKD1 kinase dead cells, silac, replicate 2.2
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe004047 | PeptideAtlas
ProteomicsHs_HEK293_2012_SILAC_Phospho_3_OrbiXL
Human HEK293T, Parental FlpIN T-Rex293, PKD1 kinase dead cells, silac, replicate 3.2
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe004042 | PeptideAtlas
ProteomicsProfiling the interactome of oligonucleotide drugs by proximity biotinylation
Drug-ID applies proximity biotinylation to identify drug-protein interactions inside living cells. The covalent conjugation of a drug molecule with a biotin ligase enables targeted biotinylation of the drug-bound proteome and its identification by SILAC-MS/MS. We investigate the interactome of two w...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD045992 | Pride
Antisense oligonucleotide Basu Proximity biotinylation Drug protein interactome Live cell Biotin ligase Hdac inhibitors Silac In situ biotinylation Bet inhibitors Bioid 
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