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Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in energy state has remained unaddressed. Here, we show that sensory food perception rapidly induces mitochondrial fission in the liver via protein ki...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-28 | PXD044227 | Pride
Adaptation of liver to the postprandial state requires coordinate regulation of protein synthesis and folding aligned with changes in lipid metabolism. Here we demonstrate that sensory food perception is sufficient to elicit early activation of hepatic mTOR-signaling, Xbp1-splicing, increased expres...
ORGANISM(S): Mus musculus 
2018-10-31 | GSE118973 | GEO
mRNA-seq of effects of food perception in C. elegans
Sensory Food Perception Rapidly Primes Postprandial ER-Homeostasis through Melanorcortin-Dependent Control of Liver mTOR Activation
The sensation of hunger after a period of fasting and the sensation of satiety after eating is crucial to behavioral regulation of food intake, but the biological mechanisms regulating these sensations are incompletely understood. We studied the behavioral and physiological adaptation to fasting in ...
ORGANISM(S): Drosophila melanogaster 
Mice were starved overnight and divided into three groups: a) refed for 30 min b) caged food (not able to reach, but to smell and see food) c) further fasted. The aim of the study was to determine phosphorylation events in the liver in response to visual exposure of food. See more details in the man...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-31 | PXD005681 | Pride
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