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ProteomicsIsolation of mouse and human MHC class I- and II-associated peptides for the analysis of immunopeptidomes by mass spectrometry
Immunopeptidomics is an emerging field that fuels and guides the development of vaccines and immunotherapies. More specifically, it refers to the science of investigating the composition of peptides presented by major histocompatibility complex (MHC) class I and class II molecules using mass spectro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-07 | PXD028633 | Pride
Mhc class i associated peptides Mass spectrometry Human Immunopeptidome Mhc class ii associated peptides Mouse 
UnknownAssociation of obesity with DNA mismatch repair status and clinical outcome in patients with stage II or III colon carcinoma participating in NCCTG and NSABP adjuvant chemotherapy trials.
Not available
S-EPMC3269966 | biostudies-literature
MetabolomicsMetabolomic Responses of Guard Cells and Mesophyll Cells to Bicarbonate
Anthropogenic CO2 presently at 400 ppm is expected to reach 550 ppm in 2050, an increment expected to affect plant growth and productivity. Paired stomatal guard cells (GCs) are the gate-way for water, CO2, and pathogen, while mesophyll cells (MCs) represent the bulk cell-type of green leaves mainly...
2017-03-31 | MTBLS309 | MetaboLights
ProteomicsTowards an upgraded honey bee (Apis mellifera L.) genome annotation using proteogenomics.
The honey bee is a key pollinator in many agricultural operations as well as a model organism for studying the genetics and evolution of social behaviour. The Apis mellifera genome has been sequenced and annotated twice over, enabling proteomics and functional genomics methods for probing relevant a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Apis mellifera (Honeybee) Drosophila melanogaster (Fruit fly) Saccharomyces cerevisiae (Baker's yeast) Caenorhabditis elegans 
2016-01-18 | PXD002275 | Pride
Honey bees Proteogenomics Mass spectrometry Gene annotation Apis mellifera 
TranscriptomicsThe time-series gene expression data in PMA stimulated THP-1
(1) qPCR Gene Expression Data The THP-1 cell line was sub-cloned and one clone (#5) was selected for its ability to differentiate relatively homogeneously in response to phorbol 12-myristate-13-acetate (PMA) (Sigma). THP-1.5 was used for all subsequent experiments. THP-1.5 cells were cultured in ...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-15528 | biostudies-arrayexpress
ProteomicsDendritic cells infected with Salmonella enterica
Salmonella enterica causes serious global burden of morbidity and mortality and is a major cause of infant bacteremia in sub Saharan Africa. Diseases caused by Salmonella are treatable with antibiotics but successful antibiotic treatment has become difficult due to antimicrobial resistance. An effec...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD004451 | Pride
Antigens Typhoid fever Vaccine development 
ProteomicsSystems biology of blood and tissue for comprehensive analysis of immune response to hepatitis B vaccine in adults
Protein concentrations of both lysed WBC and plasma samples were measured by the PierceTM Bradford Assay and normalized to contain 10 μg per sample before proceeding with sample digestion using the procedure as previously described44. Peptides were desalted using STop-And-Go Extraction tips (STAGE t...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD020474 | Pride
Tissue Blood Systems biology Hepatitis b vaccone 
MetabolomicsA Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.

BACKGROUND & AIMS: Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on pu...

2024-10-18 | MTBLS3476 | MetaboLights
ProteomicsVarroa destructor LC-MSMS crossing developmental stages and sexes
Varroa destructor is one of the most prevalent and economically damaging honey bee pests worldwide, weakening colonies by simultaneously parasitizing and transmitting damaging viruses. Despite these impacts on honey bee health, surprisingly little is known about its fundamental molecular biology. He...
ORGANISM(S): Varroa destructor 
2017-09-06 | PXD006072 | Pride
Lc-msms Development Protein atlas Varroa destructor 
ProteomicsIntegrated systems analysis reveals conserved gene networks underlying response to spinal cord injury
Spinal cord injury (SCI) is a devastating neurological condition for which there are currently no effective treatment options to restore function. A major obstacle to the development of new therapies is our fragmentary understanding of the coordinated pathophysiological processeses triggered by dama...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-09-25 | PXD010192 | Pride
Rat Spinal cord injury 
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