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ProteomicsFracture hematoma proteomics: surgical invasiveness characterizes the early fracture healing cascade after multiple trauma
Purpose The aim of this study was to determine the fracture hematoma (fxH) proteome after multiple trauma using label free proteomics, comparing two different established surgical treatment strategies. Basic procedures A large animal (sus scrofa), multiple trauma animal model was used in which two ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-05-24 | PXD049002 | Pride
Proteomics Trauma Lc-ms Fracture hematoma 
GenomicsFracture Hematoma Micro-Architecture Plays a Crucial Role in Determining Bone Healing Outcomes
Fracture Hematoma Micro-Architecture Plays a Crucial Role in Determining Bone Healing Outcomes
PRJNA677868 | ENA
TranscriptomicsFracture Hematoma Micro-Architecture Plays a Crucial Role in Determining Bone Healing Outcomes
The fracture hematoma that forms between the broken fragments of bone serves as a natural fibrin scaffold. However, there is no data regarding the differences between the micro-architectural and biological properties of hematomas formed in normally healing, delayed healing, and non-healing bone defe...
ORGANISM(S): Rattus norvegicus 
2023-11-01 | GSE161315 | GEO
TranscriptomicsMultimodal single cell profiling of bone fracture microenvironment
Age-specific alterations of the adaptive immune system include low-grade chronic inflammation, which contributes to the unfavorable outcome of the bone healing process in the elderly. In this work, we aimed to characterize the effect of immune experience and age on cellular phenotype during the earl...
ORGANISM(S): Mus musculus 
2025-02-25 | GSE273792 | GEO
GenomicsMultimodal single cell profiling of bone fracture microenvironment
Multimodal single cell profiling of bone fracture microenvironment
PRJNA1143063 | ENA
UnknownFirst report of lumbar spinal epidural hematoma after pelvic ring fracture.
Not available
S-EPMC10336082 | biostudies-literature
ProteomicsIntegration of Proteomics and Intact N-Glycoproteomics Reveals the Mechanisms Underlying BMSC Osteogenesis in the Context of Fracture Hematoma
The precise proteomic and glycoproteomic in fracture hematoma and their clinical significance are unknown. This study performed precise proteomic and N-glycoproteomic analyses of fracture hematoma from both young and elderly patients, and identified many osteogenic-related proteins and their complet...
ORGANISM(S): Homo Sapiens 
2026-03-18 | PXD075826 |
TranscriptomicsExpression data from fracture hematoma tissue of young and old rats after 3days of rigid or semi-rigid fixation of an osteotomy
The long-term healing outcome of bone regeneration is known to depend not only on mechanical stability, but also on age and, more importantly, on the overlap of both parameters. Although especially the early healing period determines the healing outcome, it so far remains unclear which factor - mech...
ORGANISM(S): Rattus norvegicus 
2014-12-31 | GSE53256 | GEO
TranscriptomicsSingle nuclei RNAseq of the periosteal response to bone fracture and musculoskeletal traumatic injury in mice
Bone regeneration is a highly efficient process allowing scarless healing after injury. Yet, musculoskeletal traumatic injury, when fracture is combined with adjacent muscle injury, alters bone healing leading to fibrous nonunion. The periosteum, the outer layer of bones, is a critical source of ske...
ORGANISM(S): Mus musculus 
2024-10-22 | GSE268276 | GEO
UnknownHematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair.
Not available
S-EPMC10413008 | biostudies-literature
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