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TranscriptomicsTo analyze the effect of loss of mitochondria on the transcriptome of Candida albicans
This set of experiment was done in order to analyze the effect of a dysfunctional mitochondria on C. albicans. The mutant was obtained by deleting the gene FZO1, which is known to be involved in mitochondrial biogenesis in S. cerevisiae. We show that the deletion of FZO1 leads to a change in mitocho...
ORGANISM(S): Candida albicans 
2013-12-05 | E-GEOD-46003 | biostudies-arrayexpress
GenomicsDNA copy number, including telomeres and mitochondria, assayed using next-generation sequencing
DNA copy number variations occur within populations and aberrations can cause disease. We sought to develop an improved lab-automatable, cost-efficient, accurate platform to profile DNA copy number. We developed a sequencing-based assay of nuclear, mitochondrial, and telomeric DNA copy number that ...
ORGANISM(S): Homo sapiens 
2010-04-02 | E-GEOD-21159 | biostudies-arrayexpress
ProteomicsMIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans
Precise regulation of mitochondrial fusion and fission is essential for cellular activity and animal development. Imbalances between these processes can lead to fragmentation and loss of normal membrane potential in individual mitochondria. In this study, we show that MIRO-1 is stochastically elevat...
ORGANISM(S): Caenorhabditis Elegans 
2023-05-10 | PXD040748 |
UnknownMacroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis.
Not available
S-EPMC5010050 | biostudies-literature
UnknownFragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.
Not available
S-EPMC6764589 | biostudies-literature
TranscriptomicsDemethyl fructiculin A (SCO-1) induces apoptosis by inducing reactive oxygen species in mitochondria
Demethyl fructiculin A is a diterpenoid quinone component of the exudates from Salvia corrugata (SCO-1) leafes. SCO-1 was recently reported to induce anoikis in mammalian cell lines via a molecular mechanism involving the presence of the membrane scavenging receptor CD36. However, experiments perfor...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-19846 | biostudies-arrayexpress
UnknownRNA-level unscrambling of fragmented genes in Diplonema mitochondria.
Not available
S-EPMC3594288 | biostudies-literature
UnknownInfection-induced peripheral mitochondria fission drives ER encapsulations and inter-mitochondria contacts that rescue bioenergetics.
Not available
S-EPMC11347691 | biostudies-literature
ProteomicsIn Situ Structural Restraints from Crosslinking Mass Spectrometry in Human Mitochondria
The field of structural biology is increasingly focusing on studying proteins in situ, i.e. in a larger biological context. Crosslinking mass spectrometry is contributing to this effort, typically through the use of MS-cleavable crosslinkers. Here, we apply the popular non-cleavable crosslinker disu...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD014675 | Pride
Crosslinking mass spectrometry Human mitochondria In situ large-scale structural biology Non-cleavable dss crosslinker Comparative modelling 
Proteomicsbreast cancer mitochondria pulldown
pull-down of protein extracted from isolated mitochondria fraction
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD030730 | Pride
Cancer Mitochondria Pull-down 
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