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ProteomicsA gatekeeper residue controls transcriptional activity of the extracellular signal-regulated protein kinase 5 (ERK5) through molecular interactions with the C terminal tail.
We analyzed the interactome of the kinase ERK5 and its mutant Y733E in HeLa cells.
ORGANISM(S): Homo sapiens (Human) 
2020-01-31 | PXD014028 | Pride
Erk5 Human 
ProteomicsERBB2 signalling and functions in oesophageal cancer
Oesophageal adenocarcinoma (OAC) is a deadly disease with poor survival statistics and few targeted therapies available. One of the most common molecular aberrations in OAC is amplification or activation of the receptor tyrosine kinase ERBB2, and ERBB2 is targeted in the clinic for this subset of pa...
ORGANISM(S): Homo sapiens (Human) 
2023-01-03 | PXD029180 | Pride
Errb oesophageal cancer phosphoproteomics 
ProteomicsProximal Phosphoproteomics Approaches revealed a FGFR-EGFR functional cross-talk
We developed Proximal Phosphoproteomics Approaches (PPAs)to study RTK endocytosis-dependent proximal signaling in breast cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2021-04-23 | PXD018184 | Pride
Rtks fgfr egfr trafficking quantitative phosphoproteomics proximal signalingdata integration 
ProteomicsSignalling and recycling endosomes_dataset 02
We studied Receptor Tyrosine Kinase signalling from recycling endosomes and how this affected downstream responses.
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD028330 | Pride
Signalling Human Label free Lc-ms/ms 
ProteomicsSignalling and recycling endosomes_dataset 03
We studied Receptor Tyrosine Kinase signalling from recycling endosomes and how this affected downstream responses. We developed a new method to study signalling in the proximity of recycling endosomes by combining enrichment of biotinylated peptides followed by enrichment of phosphorylated peptides...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD028371 | Pride
Signalling Human Label free Lc-ms/ms 
ProteomicsDGAT1 phosphoproteome and long-term proteome
Enhanced fatty acid (FA) synthesis and uptake underpin the sustained membrane biogenesis and ATP production required for melanoma cell growth and division1-4. However, to thrive, melanoma cells must avoid a potential reduction in cell growth signalling, rampant reactive oxygen species (ROS) generati...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD017487 | Pride
Dgat1 melanoma a229500 a375 
ProteomicsSignalling and recycling endosome_dataset 01
We studied Receptor Tyrosine Kinase signalling from recycling endosomes and how this affected downstream responses.
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD028370 | Pride
Signalling Q/exactive hf Human Label free 
ProteomicsProtease Regulation by Subtrate O-Glycosylation
In this study, we systematically assessed the fine-tuning of limited proteolysis in the extracellular space by glycosylation, one of the most widely observed PTMs, using cells, and applying the Terminal Amine Labeling of Substrates (TAILS) approach, a quantitative proteomics workflow for the system-...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050581 | Pride
Ptms Proteomics Degradomics 
ProteomicsProtease Regulation by Subtrate O-Glycosylation
In this study, we systematically assessed the fine-tuning of limited proteolysis in the extracellular space by glycosylation, one of the most widely observed PTMs, using cells, and applying the Terminal Amine Labeling of Substrates (TAILS) approach, a quantitative proteomics workflow for the system-...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050647 | Pride
Glycoproteomics Proteomics Degradomics 
ProteomicsProtease Regulation by Subtrate O-Glycosylation
In this study, we systematically assessed the fine-tuning of limited proteolysis in the extracellular space by glycosylation, one of the most widely observed PTMs, using cells, and applying the Terminal Amine Labeling of Substrates (TAILS) approach, a quantitative proteomics workflow for the system-...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050580 | Pride
Ptms Proteomics Degradomics 
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