Sort   by:  
 Page size 
MetabolomicsMetabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses
Atypical myopathy (AM) is a severe rhabdomyolysis syndrome that occurs in grazing horses. Despite the presence of toxins in their blood, all horses from the same pasture are not prone to display clinical signs of AM. The objective of this study was to compare the blood metabolomic profiles of horses...
2021-08-31 | MTBLS2579 | MetaboLights
ProteomicsSLP76 interactome in resting and activated primary mast cells
We used a knock-in (KI) mouse expressing SLP-76 with a C-terminal One-Strep-Tag (OST). Such a system allowed the replacement in the genome of SLP-76 by its tagged version and its expression in physiological amounts. Then, by combining high affinity purification and label-free quantitative proteomics...
ORGANISM(S): Mus musculus (Mouse) 
2013-08-28 | PXD000052 | Pride
Interactomics Slp76 Quantitative mass spectrometry 
ProteomicsCK2β is a gatekeeper of focal adhesions regulating cell spreading
CK2 is an hetero-tetrameric protein made of two CK2α catalytic subunits and two regulatory CK2β subunits. The free CK2α subunit and the tetrameric holoenzyme have distinct substrate specificity profiles suggesting that the spatiotemporal organization of the individual CK2 subunits observed in living...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD030991 | Pride
Proteomics Tyrosine phosphorylated proteins Ck2β depletion Lc-ms/ms 
ProteomicsA Specific RAGE Phosphorylation by CK2 in human Amniotic Epithelial cell model
The receptor for advanced glycation end products (RAGE) is a multiligand, immunoglobulin-like transmembrane protein expressed in various cell types and implicated in a broad spectrum of diseases linked with epithelial dysfunctions. Despite significant progress in structural studies, the details of i...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD064008 | Pride
Rage / ck2 / phosphorylation 
ProteomicsRibosomal protein signature in adult mouse organs
we purified the ribosomal fraction from 14 different adult mouse tissues and analyzed their protein composition using quantitative mass spectrometry (MS)-based proteomics. We show that ribosomes exhibit heterogeneity in RP composition, not only in the case of RP paralogues (e.g. in muscle and testis...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD044060 | Pride
Ribosome Mouse Quantification Lc-ms/ms 
ProteomicsGuidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system
Long-distance regeneration of the central nervous system (CNS) has been achieved from the eye to the brain through activation of neuronal molecular pathways or pharmacological approaches. Characterizing the mature neuronal environment is essential to understand the adult axonal guidance in order to ...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-20 | PXD029325 | Pride
Lc-ms/ms Qexactive hf Cns Mouse 
ProteomicsBioinformatics and mass spectrometry-based proteomics reveal alcohol dehydrogenase 1B as a blood biomarker candidate to monitor acetaminophen-induced liver injury
Acute liver injury (ALI) is a severe disorder resulting from excessive hepatocyte cell death and frequently caused by acetaminophen intoxication. Clinical management of ALI progression is hampered by the dearth of blood biomarkers available. In this study, a bioinformatics workflow was developed to ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-29 | PXD028082 | Pride
Proteomics  mass spectrometry  liver  blood  biomarker  acetaminophen 
ProteomicsRibosomal protein L5 (RPL5/uL18) I60V mutation is associated to increased translation and modulates drug sensitivity in T-cell acute lymphoblastic leukemia cells
Somatic mutations in ribosomal proteins (RPs), including RPL5, have been reported in approximately 10% of pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL). In cancer, the incorporation of mutant RPs into ribosomes often disrupts canonical ribosome function, thereby contributing to...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD064727 | Pride
Ribosomes Target therapy Cancer Lc-ms/ms 
ProteomicsIdentification of RPL9 variants incorporated in mature ribosomes from patient's Lymphoblastoid cell line
Variants in ribosomal protein (RP) genes drive Diamond-Blackfan anemia (DBA), a bone marrow failure syndrome that can also predispose individuals to cancer. Inherited and sporadic RP gene variants are also linked to a variety of phenotypes, including malignancy, in individuals with no anemia. Here w...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-10 | PXD015218 | Pride
Ribosomes Rpl9 variants Label-free quantification Nanolc-ms/ms 
ProteomicsPlasma ALS and LG3BP predict liver fibrosis in NAFLD patients
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 25% of the world’s population and its prevalence is increasing with the rise in obesity. The evolution of this disease includes different pathological stages: steatosis, inflammation, fibrosis, cirrhosis and hepatocellular carcinoma (H...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD043340 | Pride
Plasma nafld biomarkers discovery 
Sort   by:  
 Page size