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ProteomicsInflammatory Activation Drives Re-Sculpting and Shear-Thinning of the Dendritic Cell Nucleus
To mount an adaptive immune response, dendritic cells must migrate to lymph nodes to present antigens to T cells. Critical to 3D migration is the nucleus, which is the size-limiting barrier for migration through the extracellular matrix. Here, we show that inflammatory activation of dendritic cells ...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD031056 | Pride
Dendritic cells Lc-ms/ms 
ProteomicsQuantitative proteomics and phosphoproteomics analysis of patient-derived ovarian cancer stem cells
High-grade serous ovarian carcinoma (HGSOC) is the deadliest gynecologic cancer. Key to the progression and ultimate lethality of this subtype is the intra-tumoral heterogeneity (ITH), which is defined as the coexistence of different cell types and populations within a single tumor. Among those, ova...
ORGANISM(S): Homo sapiens (Human) 
2025-04-24 | PXD061015 | Pride
Cancer stem cells Orbitrap exploris 480 Ovarian cancer 
ProteomicsQuantitative proteomics and phosphoproteomics analysis of patient-derived ovarian cancer stem cells
High-grade serous ovarian carcinoma (HGSOC) is the deadliest gynecologic cancer. Key to the progression and ultimate lethality of this subtype is the intra-tumoral heterogeneity (ITH), which is defined as the coexistence of different cell populations within a single tumor. Among those, ovarian cance...
ORGANISM(S): Homo sapiens (Human) 
2026-09-13 | PXD055524 | Pride
Dia Cancer stem cells Tmt Orbitrap exploris 480 Evosep Hgsoc Ovarian cancer 
ProteomicsMatrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancer
Ovarian cancer (OC) displays the highest mortality among gynecological tumors, mainly due to early peritoneal dissemination, the high frequency of tumor relapse following primary debulking and the development of chemoresistance. All these events are thought to be initiated and sustained by a subpopu...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037543 | Pride
Exploris 480  matrix gla protein  ovarian cancer  cancer stem cells  tumor initiation  hedgehog pathway 
ProteomicsMultilayered proteomics uncovers Notch/PKC targeting to overcome resistance to Notch inhibition in acute lymphoblastic leukemia
NOTCH1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage and subsequent activation, has been limited due to to...
ORGANISM(S): Homo sapiens (Human) 
2021-03-08 | PXD018744 | Pride
Proteomics Pkcδ Notch signaling Drug resistance T-all 
ProteomicsTyr62 phosphorylation of the phosphatase SHP2 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
The protein tyrosine phosphatase SHP2 is crucial for oncogenic transformation of acute myeloid leukemia (AML) cells expressing mutated receptor tyrosine kinases (RTKs), as it is required for full RAS-ERK activation to promote cell proliferation and survival programs. SHP2 allosteric inhibitors act b...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD030338 | Pride
Shp2 Ptpn11 Proteomics Drug resistance Aml 
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