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ProteomicsChemical Genetic Identification of Cyclin-G-associated kinase (GAK) Substrates Reveals its Role in Regulating Na+/K+-ATPase and Sipa1L1 in Neurons
Recent genetic evidence implicates the serine/threonine kinase cyclin G-associated kinase (GAK) as a Parkinson’s disease risk. However, its role in neuronal function and many downstream effectors remain unclear. Employing a chemical genetics method, we show here that the sodium potassium pump (Na+...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-07 | PXD011319 | Pride
Cyclin-g-associated kinase Sodium potassium pump Atp1a3 Gak 
UnknownChemical genetic identification of GAK substrates reveals its role in regulating Na<sup>+</sup>/K<sup>+</sup>-ATPase.
Not available
S-EPMC6312924 | biostudies-literature
UnknownCharacterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.
Not available
S-EPMC9894841 | biostudies-literature
UnknownA small molecule inhibitor of HER3: a proof-of-concept study.
Not available
S-EPMC7489893 | biostudies-literature
ProteomicsE3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion
The ubiquitin-proteasome system maintains protein homeostasis, underpins the cell cycle and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated proteolysis, remains incompletely understood. Identified through screening f...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-23 | PXD025237 | Pride
Immune evasion E3 ubiquitin ligase Melanoma 
UnknownThe structural mechanism of dimeric DONSON in replicative helicase activation.
Not available
S-EPMC7616792 | biostudies-literature
UnknownDifferential chromatin accessibility response to retinoic acid in neuroblastoma with ATRX in-frame-deletions versus ATRX loss-of-function.
Not available
S-EPMC12753499 | biostudies-literature
UnknownNatural proteome diversity links aneuploidy tolerance to protein turnover.
Not available
S-EPMC11153158 | biostudies-literature
UnknownInhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface.
Not available
S-EPMC5929906 | biostudies-literature
UnknownEpi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation.
Not available
S-EPMC11615350 | biostudies-literature
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