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We describe an in depth analysis in fission yeast of changes in the phosphoproteome after inhibition of the TOR protein kinases. A total of 756 phosphosites on 316 proteins showed significant and rapid changes in phosphorylation levels after TOR kinase inhibition when the rate of protein synthesis r...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2021-07-09 | PXD023664 | Pride
Cyclin dependent kinases (CDKs) lie at the heart of eukaryotic cell division, with different CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs)1-3. However, the principles on which cyclin-CDKs organise the cell cycle are still contentious, with current theories suggesting that ei...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2022-03-22 | PXD029073 | Pride
Human HOS cell line was differentiated by beta-glycerophosphate (BGP) treatment and gene expression profiling was studied with Illumina expression microarray (HumanHT12_V4). Three negative control replicates vs. three BGP 3-day treatment replicates
ORGANISM(S): Homo sapiens 
Cell cycle events are ordered by cyclin-dependent kinases (CDKs), which phosphorylate hundreds of substrates. Multiple phosphatases oppose these CDK substrates, yet their collective role in regulating phosphorylation timing in vivo remains unclear. Here, we show that four phosphatases (PP2A-B55, PP2...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-10-05 | PXD060298 | Pride
Wnt signalling coordinates growth and cell fate decisions during development and mis-regulation of Wnt signalling in adults is associated with a range of conditions, including cancer and neurogenerative diseases. Therefore, means of modulating Wnt proteins and/or cofactors could have significant the...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-08-13 | PXD051416 | Pride
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