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UnknownFirst record of Trypanosoma evansi DNA in Dichelacera alcicornis and Dichelacera januarii (Diptera: Tabanidae) flies in South America.
Not available
S-EPMC9817266 | biostudies-literature
ProteomicsAggregate-selective removal of pathological tau via clustering-activated degraders
Homotypic protein assembly is a critical mediator of biological function and disease state. Selective degradation of protein assemblies, while sparing monomeric forms, is required for interrogation of biological mechanisms and assembly-specific therapeutic intervention. We have exploited the require...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052957 | Pride
Neurodegenerative diseases Trim21 Tau 
UnknownHighly Enantioselective Lewis Acid Catalyzed Conjugate Addition of Imidazo[1,2-a]pyridines to α,β-Unsaturated 2-Acylimidazoles under Mild Conditions.
Not available
S-EPMC11197092 | biostudies-literature
ProteomicsCo-opting templated aggregation to selectively degrade pathogenic tau assemblies
Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here we describe a therapeutic strategy called ‘RING-Bait’ which employs an aggregating protein sequence combined with an...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052897 | Pride
Proteinopathies 
UnknownCatalyst- and metal-free C(sp2)-H bond selenylation of (N-hetero)-arenes using diselenides and trichloroisocyanuric acid at room temperature.
Not available
S-EPMC10471583 | biostudies-literature
ProteomicsSocial status and ejaculate investment in the house mouse c4pr_liv
Sperm competition theory predicts that males should tailor ejaculates according to their social status. Here we test this in a model vertebrate, the house mouse (Mus musculus domesticus), combining experimental data with a quantitative proteomics analysis of seminal fluid composition. Our analyses r...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019727 | Pride
Lc-ms Lfq Sperm competition 
ProteomicsTemporal modulation of the NF-kB network in response to different types of DNA damage ETOPOSIDE C4PR_LIV
Different types of DNA damage can initiate phosphorylation-mediated signalling cascades that result in stimulus specific pro- or anti-apoptotic cellular responses. Amongst its many roles, the NF-κB transcription factor RelA is central to the DNA damage response pathway. Yet, understanding of the co-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019587 | Pride
Dna damage  rela  p65  nf-κb  phosphorylation  mass spectrometry Phosphoproteomics  etoposide  hydroxyurea 
ProteomicsTemporal modulation of the NF-kB network in response to different types of DNA damage HYDROXYUREA C4PR_LIV
Different types of DNA damage can initiate phosphorylation-mediated signalling cascades that result in stimulus specific pro- or anti-apoptotic cellular responses. Amongst its many roles, the NF-κB transcription factor RelA is central to the DNA damage response pathway. Yet, understanding of the co-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019589 | Pride
Dna damage  rela  p65  nf-κb  phosphorylation  mass spectrometry Phosphoproteomics  etoposide  hydroxyurea 
ProteomicsSynthetic biology meets proteomics: Construction of à la carte QconCATs for absolute protein quantification C4PR_LIV
We report a new approach to the assembly and construction of QconCATs, quantitative concatamers for proteomic applications that yield stoichiometric quantities of sets of stable isotope-labelled internal standards. The new approach is based on synthetic biology precepts of biobricks, making use of ...
ORGANISM(S): Escherichia coli 
2021-11-15 | PXD027521 | Pride
Synthetic biology Qconcat Quantitative proteomics Loop assembly 
ProteomicsReproductive cooperation - Main study C4PR_LIV
By successfully tracking individual maternal food intake and milk investment, we show that offspring gain more milk from their own mother, particularly when partner mothers are unrelated and when offspring born second experience strong competition from older pups. Unrelated partner mothers are less ...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-27 | PXD019578 | Pride
Lc-ms Labeled quantification 
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