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UnknownFirst record of Trypanosoma evansi DNA in Dichelacera alcicornis and Dichelacera januarii (Diptera: Tabanidae) flies in South America.
Not available
S-EPMC9817266 | biostudies-literature
ProteomicsAggregate-selective removal of pathological tau via clustering-activated degraders
Homotypic protein assembly is a critical mediator of biological function and disease state. Selective degradation of protein assemblies, while sparing monomeric forms, is required for interrogation of biological mechanisms and assembly-specific therapeutic intervention. We have exploited the require...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052957 | Pride
Neurodegenerative diseases Trim21 Tau 
UnknownHighly Enantioselective Lewis Acid Catalyzed Conjugate Addition of Imidazo[1,2-a]pyridines to α,β-Unsaturated 2-Acylimidazoles under Mild Conditions.
Not available
S-EPMC11197092 | biostudies-literature
ProteomicsCo-opting templated aggregation to selectively degrade pathogenic tau assemblies
Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here we describe a therapeutic strategy called ‘RING-Bait’ which employs an aggregating protein sequence combined with an...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052897 | Pride
Proteinopathies 
UnknownCatalyst- and metal-free C(sp2)-H bond selenylation of (N-hetero)-arenes using diselenides and trichloroisocyanuric acid at room temperature.
Not available
S-EPMC10471583 | biostudies-literature
ProteomicsSocial status and ejaculate investment in the house mouse c4pr_liv
Sperm competition theory predicts that males should tailor ejaculates according to their social status. Here we test this in a model vertebrate, the house mouse (Mus musculus domesticus), combining experimental data with a quantitative proteomics analysis of seminal fluid composition. Our analyses r...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019727 | Pride
Lc-ms Lfq Sperm competition 
ProteomicsTemporal modulation of the NF-kB network in response to different types of DNA damage HYDROXYUREA C4PR_LIV
Different types of DNA damage can initiate phosphorylation-mediated signalling cascades that result in stimulus specific pro- or anti-apoptotic cellular responses. Amongst its many roles, the NF-κB transcription factor RelA is central to the DNA damage response pathway. Yet, understanding of the co-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019589 | Pride
Dna damage  rela  p65  nf-κb  phosphorylation  mass spectrometry Phosphoproteomics  etoposide  hydroxyurea 
ProteomicsTemporal modulation of the NF-kB network in response to different types of DNA damage ETOPOSIDE C4PR_LIV
Different types of DNA damage can initiate phosphorylation-mediated signalling cascades that result in stimulus specific pro- or anti-apoptotic cellular responses. Amongst its many roles, the NF-κB transcription factor RelA is central to the DNA damage response pathway. Yet, understanding of the co-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019587 | Pride
Dna damage  rela  p65  nf-κb  phosphorylation  mass spectrometry Phosphoproteomics  etoposide  hydroxyurea 
ProteomicsOperation of a TCA cycle subnetwork in the mammalian nucleus_mass4tox
Nucleic acid and histone modifications critically depend on central metabolism for substrates and co-factors. Although a few enzymes related to the formation of these required metabolites have been reported in the nucleus, the corresponding metabolic pathways are considered to function elsewhere in ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032238 | Pride
Tricarboxylic acid (tca) cycle Nuclear proteins Non canonical metabolism compartmentalization Gene expression regulation 
ProteomicsRevealing mechanisms of mating plug function under sexual selection C4PR_LIV
A novel proteomic approach reveals dual functions for rodent mating plugs in sperm competition.
ORGANISM(S): Myodes glareolus (Bank vole) (Clethrionomys glareolus) 
2021-09-08 | PXD011694 | Pride
Sexual competition Myodes glareolus Mating plugs Stable isotope labelled amino acid in vivo Rodent 
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