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UnknownSPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm?
Not available
S-EPMC10560177 | biostudies-literature
TranscriptomicsGene expression and genotype in normal heart
Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs133...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22253 | biostudies-arrayexpress
TranscriptomicsAdvanced Study of Aortic Pathology (ASAP)
BACKGROUND: The vast majority of thoracic aortic aneurysms (TAAs) are observed either together with a bicuspid aortic valve (BAV), a common congenital disorder, or in idiopathic cases such as patients with a normal tricuspid aortic valve (TAV). The main objective of our study was to identify shared ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-26155 | biostudies-arrayexpress
TranscriptomicsThe Stockholm Atherosclerosis Gene Expression (STAGE) study: Global Gene Expression data from coronary and carotid artery disease patients
Tissue samples have been isolated during corornary artery by-pass grafting (CABG)surgery from the atheroscelrotic arterial wall (AAW, aortic root puncture for proxmal ligation of by-pass vessel), non-atherosclertoci arterial wall (NAAW, distal part of mammary artery used a graft for LAD), liver, sk...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-40231 | biostudies-arrayexpress
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
TranscriptomicsExpression data from aortic smooth muscle cells (AoSMC) and myofibroblasts (FB) isolated respectively from the ascending aortas and the aortic valves of bicuspid (BAV) and tricuspid aortic valve (TAV) patients
AoSMC and FB were cultured and exposed to transforming growth factor beta1 (TGFb1) prior to the exon array analysis The objective was to study the TGFb responsivness, at the gene expression level, in AoSMC and FB form BAV and TAV patients 54 samples in total were generated from biopsies obtained fro...
ORGANISM(S): Homo sapiens 
2015-01-15 | E-GEOD-61128 | biostudies-arrayexpress
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