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ProteomicsProteomic Characterization of Bradyrhizobium diazoefficiens bacteroids during soybean root nodules senescence
The form and physiology of Bradyrhizobium diazoefficiens after the decline of symbiotic nitrogen fixation has been characterized. Proteomic analyses showed that the post-symbiotic B. diazoefficiens undergo metabolic remodeling as well defined groups of proteins declined, increased or remained unchan...
ORGANISM(S): Bradyrhizobium japonicum USDA 110 
2019-11-12 | PXD011604 | Pride
Nitrogen fixation Bradyrhizobium diazoefficiens Soybean Senescence 
ProteomicsDistinct Combinatorial Cascade of Events Generated by ECM Proteolysis Dictates Cell Behavior, part 2
It is well established that the expression profiles of multiple and possibly redundant matrix remodeling proteases (e.g. collagenases) strongly differentiates in disease and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in-vivo activity ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-27 | PXD003796 | Pride
Proteomics Ecm 
TranscriptomicsTranscription profiling by array of adult zebrafish control and post-lesion retina to investigate the molecular determinants of retinal regeneration in adult vertebrate
Purpose: Investigate the molecular determinants of retinal regeneration in adult vertebrates by analyzing the gene expression profiles of control and post-lesion retina of adult zebrafish, a system that regenerates following injury. Methods: Gene expression profiles of zebrafish retina and brain wer...
ORGANISM(S): Danio rerio 
2005-09-16 | E-GEOD-3303 | biostudies-arrayexpress
ProteomicsDistinct Combinatorial Cascade of Events Generated by ECM Proteolysis Dictates Cell Behavior
It is well established that the expression profiles of multiple and possibly redundant matrix remodeling proteases (e.g. collagenases) strongly differentiates in disease and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in-vivo activity ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-27 | PXD003553 | Pride
Proteomics Metalloproteinase Ecm 
ProteomicsDysregulated Proteolysis of Extracellular Matrix Proteins Regulates Influenza and Pneumonia Co-infection Associated Mortality
The balance between tissue integrity and efficient immune response is critical for host survival. Here we investigate the role of extra cellular matrix (ECM)-remodeling events in the lung during influenza infection. Using an unbiased genomic and proteomic approach we follow the dynamics of gene and ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD004871 | Pride
Influenza Pneumonia Extracellular matrix proteins 
UnknownDistinct biological events generated by ECM proteolysis by two homologous collagenases.
Not available
S-EPMC5047162 | biostudies-literature
ProteomicsQuantitative Proteomics of the Cancer Cell Line Encyclopedia
The Cancer Cell Line Encyclopedia (CCLE) is a collaborative effort to generate steady-state large-scale profiling across a collection of nearly a thousand cancer cell lines. Multiple generations of this effort have resulted in a collection of many data types such as RNA expression, mutation annotati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-27 | MSV000085836 | MassIVE
TranscriptomicsDNA methylation profiles in primary cutaneous melanoma are associated with clinically significant pathologic features
We investigated whether methylation in primary melanomas is associated with tumor pathologic features or defines subgroups of primary melanomas 47 primary cutaneous melanomas were analyzed using the Illumina GoldenGate Cancer Panel I methylation array
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-54623 | biostudies-arrayexpress
UnknownAn integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
Not available
S-EPMC6089983 | biostudies-literature
GenomicsPreeclampsia InterPregGen Consortium: Large-scale GWAS meta-analysis of maternal preclampsia cases and controls from Europe and Central Asia. Plus extension of earlier European fetal preeclampsia GWAS meta-analysis (see EGAS00001001048) by adding Central Asian fetal preeclampsia cases and controls. Datasets provided under this study are GWAS meta-analysis summary statistics and individual level GWAS genotype data. Related InterPregGen Consortium data are also provided under studies EGAS00001000416 and EGAS00001000417 (whole genome sequence data for 100 unrelated Uzbeks and 100 unrelated Kazakhs) and EGAS00001001048 (European fetal preeclampsia GWAS summary statistics and genotype data
Preeclampsia (PE) is a syndrome affecting pregnant mothers and fetus/babies characterised by hypertension and proteinuria, and is a leading cause of maternal and fetal death and of premature births worldwide. The InterPregGen Consortium was funded by a European Framework 7 (FP7) grant and grew out o...
EGAS00001001266 | EGA
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