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ProteomicsA CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
Controlled gene expression is achieved through the intricate regulation of Pol II progression through transcription-cycle checkpoints. While the contribution of CDK9 for Pol II pause-release is well established, the requirement for other CDKs has not been fully elucidated. Here we propose a new role...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD066230 | Pride
Cdk11 Transcription Pause-release Leukaemia 
GenomicsPromoter capture mESC and fetal liver
Genome organization influences transcriptional regulation by facilitating interactions between gene promoters and distal regulatory elements. To analyse distal promoter contacts we used Capture Hi-C (CHi-C) to enrich for promoter-interactions in HiC libraries from mouse ESC and E14.5 fetal liver. Pl...
ORGANISM(S): Mus musculus 
2015-02-01 | E-MTAB-2414 | biostudies-arrayexpress
UnknownGenomic epidemiology offers high resolution estimates of serial intervals for COVID-19.
Not available
S-EPMC10415581 | biostudies-literature
UnknownHIV Prevention for Black Heterosexual Men: The Barbershop Talk with Brothers Cluster Randomized Trial.
Not available
S-EPMC6611102 | biostudies-literature
UnknownDecentralised, collaborative, and privacy-preserving machine learning for multi-hospital data.
Not available
S-EPMC10884342 | biostudies-literature
UnknownLearning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning.
Not available
S-EPMC11616810 | biostudies-literature
TranscriptomicsSingle cell Hi-C reveals cell-to-cell variability in chromosome structure
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformat...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-48262 | biostudies-arrayexpress
UnknownMultimorbidity and the risk of malnutrition, frailty and sarcopenia in adults with cancer in the UK Biobank.
Not available
S-EPMC11446695 | biostudies-literature
TranscriptomicsTranscriptional profiles of macrophages in resolving inflammation
We have performed a comprehensive transcriptional analysis of specific monocyte and macrophage (MM-CM-^X) subsets during an acute self-resolving inflammatory insult. Following initial induction of acute inflammation, tissue resident (Resident) MM-CM-^X are rapidly M-bM-^@M-^XclearedM-bM-^@M-^Y from ...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-28621 | biostudies-arrayexpress
UnknownImmunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant.
Not available
S-EPMC7223911 | biostudies-literature
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