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MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
ProteomicsInhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular jun...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-06 | PXD065529 | Pride
Lc-msms  aryl hydrocarbon receptor  proteomics 
TranscriptomicsEts-1 over-expression in ovarian cancer cells
The transcription factor Ets-1 is over-expressed in a wide variety of cancers, and has been strongly associated with the upregulation of factors involved in metastasis and angiogenesis. In this study, we created an inducible Ets-1 over-expressing ovarian cancer cell line from parental 2008 ovarian c...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21129 | biostudies-arrayexpress
TranscriptomicsGenome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
We present an approach for globally monitoring RNA structure in native conditions in vivo with single nucleotide precision. This method is based on in vivo modification with dimethyl sulfate (DMS), which reacts with unpaired adenine and cytosine residues9, followed by deep sequencing to monitor modi...
ORGANISM(S): Homo sapiens 
2013-12-15 | E-GEOD-45803 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of follicular lymphoma cells
The hallmark of follicular lymphoma (FL) is the t(14;18) chromosomal translocation. However, constitutive expression of anti-apoptotic Bcl-2 alone is insufficient for lymphomagenesis and subsequent molecular hits are required. We explored the role of microRNA (miRNA or miR) in the biology of FL by...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-28090 | biostudies-arrayexpress
TranscriptomicsDifferential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations
Macrophages are a heterogeneous cell type implicated in injury, repair, and fibrosis after AKI, but the macrophage population associated with each phase is unclear.results of this study in a renal ischemia-reperfusion injury model allow phenotype and function to be assigned to CD11b+/Ly6C+ monocyte/...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-75808 | biostudies-arrayexpress
TranscriptomicsMultiomic (Joint snRNA/snATAC) sequencing data of intestinal crypts and epithelial only organoids derived from human fetal duodenum
Here, we used joint single-nuclei RNA-sequencing (snRNA-seq) and single-nuclei ATAC sequencing (scATAC) to profile freshly isolated crypts from the human fetal intestine and matched intestinal epithelial only organoids (also known as enteroids) derived from these crypts after one passage of in vitro...
ORGANISM(S): Homo sapiens 
2022-07-16 | E-MTAB-11908 | biostudies-arrayexpress
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