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TranscriptomicsThe Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters
We performed ChIP-seq of histone modifications and RNA-seq in WT and kmt6 mutant Fusarium graminearum grown in high and low nitrogen conditions. Two replicates of RNA seq for WT and kmt6 strains at high and low nitrogen. Four histone modification ChIPs in WT and kmt6 mutant strains at high and low n...
ORGANISM(S): Fusarium graminearum 
2014-02-27 | E-GEOD-50689 | biostudies-arrayexpress
TranscriptomicsGenome-wide characterization of light-regulated genes in Neurospora crassa
RNA-seq from Neurospora crassa at 5 time points of light induction, with 2 replicates for each, totalling 10 samples RNA-seq from Neurospora crassa at 5 time points of light induction, with 2 replicates for each, totalling 10 samples
ORGANISM(S): Neurospora crassa 
2014-08-01 | E-GEOD-53534 | biostudies-arrayexpress
TranscriptomicsRelics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa
Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and modifications of histones and DNA. Neurospora crassa sports features of heterochromatin found in higher eu...
ORGANISM(S): Neurospora crassa 
2010-05-15 | E-GEOD-12690 | biostudies-arrayexpress
TranscriptomicsThe classical histone deacetylases FfHdF1 and FfHdF2 are both major regulators of secondary metabolism in Fusarium fujikuroi
Histone modifications have been shown to be crucial for secondary metabolism in various filamentous fungi. Here we studied the influence of histone acetylation on secondary metabolite production in the phytopathogenic fungus Fusarium fujikuroi, a known producer of several secondary metabolites inclu...
ORGANISM(S): Fusarium fujikuroi 
2013-10-05 | E-GEOD-43768 | biostudies-arrayexpress
ProteomicsSpermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model
Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been found to be another important feature contributing to AD progression. Therefo...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-04 | PXD034638 | Pride
Neuroinflammation Autophagy Phagocytosis Alzheimer’s disease Dietary supplement Spermidine Microglia Liquid chromatography tandem mass spectrometry 
UnknownROR2-specific CAR T cells are effective against hematologic and solid tumors and well tolerated in mice.
Not available
S-EPMC12629790 | biostudies-literature
UnknownGenome-wide case-only analysis of gene-gene interactions with known Parkinson's disease risk variants reveals link between LRRK2 and SYT10.
Not available
S-EPMC10310744 | biostudies-literature
GenomicsKnock-down of the methyltransferase Kmt6 reliefs H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi [ChIP-seq]
We performed ChIP-seq of H3K27me3 in wild type Fusarium fujikuroi grown in synthetic ICI medium with low nitrogen conditions. Three replicates of F. fujikuroi wild-type strain were grown in low nitrogen. ChIP-Seq was performed with anti-H3K27me3 antibody.
ORGANISM(S): Fusarium fujikuroi 
2016-07-04 | E-GEOD-80478 | biostudies-arrayexpress
TranscriptomicsKnock-down of the methyltransferase Kmt6 reliefs H3K27me3 and induces expression of cryptic otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi [gene expression]
Filamentous fungi produce a vast array of secondary metabolites (SMs) and some of them are applied in agriculture or pharmacology. Recent sequencing of the rice pathogen Fusarium fujikuroi revealed the presence of far more SM-encoding genes than known products. SM production is energy-consuming and ...
ORGANISM(S): Fusarium fujikuroi 
2016-07-04 | E-GEOD-80477 | biostudies-arrayexpress
GenomicsThe PUWMa (Pfizer-funded study from the University of California Los Angeles (UCLA), Washington University (WASH-U), and Massachusetts General Hospital (MGH)) GWAS of ADHD

The PUWMa GWAS of ADHD is a multi-site collaboration initiated to conduct a family-based association study from existing research samples. The source sample of ADHD families was ascertained at Massachusetts General Hospital (MGH, N=309 trios), Washington University at St. Louis (WASH-U, N...

phs000358.v1.p1 | EGA
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