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UnknownIleal interposition surgery targets the hepatic TGF-β pathway, influencing gluconeogenesis and mitochondrial bioenergetics in the UCD-T2DM rat model of diabetes.
Not available
S-EPMC6766639 | biostudies-literature
UnknownUpdate on Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS).
Not available
S-EPMC8629873 | biostudies-literature
ProteomicsLong non-coding RNA Neat1 is a key of translational regulator in hypoxia
Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to hypoxia, (lymph)angiogenic factors responsible for tissue revascularization in ischemic diseases are induced by the IRES-dependent mechanism. Here we searched for IRES trans-acting factors (ITAFs) active...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-03 | PXD024067 | Pride
Nanolc-ms/ms Translational control Hypoxia Cardiomyocyte Label-free quantitative proteomics 
ProteomicsAgonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
Agonists for the nociceptin/orphanin FQ opioid peptide NOP receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those for other members of the opioid receptor family. Therefore, we investig...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012908 | Pride
Brain Opioid receptor family Mouse Biological Pharmacology Post-translational modification Nanolc-ms/ms cid/etd Phosphorylation 
UnknownA grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens.
Not available
S-EPMC7224513 | biostudies-literature
ProteomicsTargeting Fibrillarin-mediated ribosomal RNA maturation as a novel therapeutic vulnerability in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is among the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Current ribosome biogenesis inhibitors primarily tar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD060027 | Pride
Label-free quantitative proteomics Targeting ribosome biogenesis Nanolc-ms/ms Triple-negative breast cancer 
ProteomicsThe Amino-Terminal Part of Human Filaggrin-2 is a Component of Cornified Envelopes
Filaggrin-2 (FLG2), a member of the S100-fused type protein family, is a 250 kDa protein mainly expressed in differentiated keratinocytes of the epidermis (Wu et al., 2009; Hsu et al., 2011). Its expression is reduced in atopic dermatitis (Pellerin et al., 2013), and heterozygous non-sense mutations...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD011833 | Pride
Keratinocyte Proteomics Corneocyte Transglutaminase Terminal differentiation Epidermis 
ProteomicsMitochondrial ribosomal protein MRPS15 Is a component of cytosolic ribosomes and regulates translation in stressed cardiomyocytes
Regulation of mRNA translation is a crucial step in controlling gene expression in stressed cells, impacting many pathologies, including heart ischemia. In recent years, ribosome heterogeneity has emerged as a key control mechanism driving the translation of subsets of mRNAs. In this study, we inves...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050321 | Pride
Ribosome heterogeneity  mitochondrial ribosomal protein  translational control  ires  endoplasmic reticulum stress  cardiomyocyte  proteomics 
ProteomicsAttachment of the RNA degradosome to the inner cytoplasmic membrane of Escherichia coli prevents wasteful degradation of rRNA intermediates in ribosome assembly.
RNase E, an essential endoribonuclease in Escherichia coli, is the key component of the multienzyme RNA degradosome, which is localized to the inner cytoplasmic membrane. Until now, the reason for membrane localization of RNase E was not known. We have analyzed ribosome assembly in the rneΔMTS strai...
ORGANISM(S): Escherichia coli 
2023-01-16 | PXD038317 | Pride
Ribosome assembly Rnase e Rna degradosome Label-free quantitative proteomics Nanolc-ms/ms 
UnknownEffect of different levels of feed restriction and fish oil fatty acid supplementation on fat deposition by using different techniques, plasma levels and mRNA expression of several adipokines in broiler breeder hens.
Not available
S-EPMC5783386 | biostudies-literature
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