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MetabolomicsMetabolic reaction network-based recursive metabolite annotation for untargeted metabolomics (Aging fruit fly negative mode)

Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network (MRN)-based recursive algorithm (MetDNA) that expands metabolite annotations without the need for a comprehensive standard...

2019-03-26 | MTBLS615 | MetaboLights
MetabolomicsMetabolic reaction network-based recursive metabolite annotation for untargeted metabolomics (Aging fruit fly positive mode)

Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network (MRN)-based recursive algorithm (MetDNA) that expands metabolite annotations without the need for a comprehensive standard...

2019-03-22 | MTBLS612 | MetaboLights
ProteomicsDirect proteome labelling in fruit flies with SILAF reveals differential phosphorylation of mitochondrial proteins upon loss of OXPHOS subunits
Drosophila melanogaster has been a workhorse of genetics and cell biology for more than a century. However, proteomic-based methods have been limited due to the complexity and dynamic range of the fly proteome and the lack of efficient labelling methods. Here, we advanced a chemically defined food s...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-10 | PXD009990 | Pride
Holidic Fly Silaf Bsf Fruit fly Oxphos Lrpprc Silac Drosophila Methods development Drosophila melanogaster 
TranscriptomicsNascent-seq indicates widespread cotranscriptional RNA editing in Drosophila
The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila, by isolating nascent RNA from adult fly heads and subjecting samples to high-throughput sequencing. There ...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-37232 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of fruit flies overexpressing the Atg1 gene
Overexpression of Atg1 using either weaker CGGAL4 or stronger HRGAL4 driver. Both drivers have same expression pattern and are specific for intestine, Malpighian tubules and fat body of the fruit fly Drosophila melanogaster. Weaker Atg1 overexpression results in longer lifespan whereas stronger Atg1...
ORGANISM(S): Drosophila melanogaster 
2020-07-15 | E-MTAB-9391 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila mutant for transcription factors Dorsal, Dif, and Relish and their effect on immune response
The abstract of the manuscript titled "Microarray analyses reveal possible new targets for the Rel protein Dif in Drosophila melanogaster " is given below: ; The fruit fly Drosophila melanogaster express three closely related NF-κB-like transcription factors: Dorsal, Dif, and Relish. They share sig...
ORGANISM(S): Drosophila melanogaster 
2008-06-13 | E-GEOD-5489 | biostudies-arrayexpress
ProteomicsCoRest’s acetylation acts as a temporal gate for activity-dependent transcription, limiting behavioral flexibility in Drosophila
In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2020-12-07 | PXD021294 | JPOST Repository
TranscriptomicsTranscription profiling of Drosophila pooled Malpighian tubules vs. whole fly
This is an affymetrix array experiment comparing the transcriptome of the Malpighian tubule (or renal tubule) of 7-day adult Oregon R strain Drosophila melanogaster with matched whole fly samples. It is described in:,Wang, J., Kean, L., Yang, J., Allan, A. K., Davies, S. A., Herzyk, P. and Dow, J. A...
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-1690 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of a Drosophila melanogaster mitochondrial deoxynucleotide transporter dRIM2.
We have studied the deoxynucleotide transport in Drosophila melanogaster. On the basis of homology with the S. cerevisiae RIM2 gene, encoding a pyrimidine deoxynucleotide carrier (Marrobbio et al. 2006), the CG18317 gene (dRIM2) in the fruit fly may code for a deoxynucleotide carrier. We demonstrate...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-48012 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of selenophosphate synthetase 2 knockdown in Drosophila melanogaster
Selenium (Se) is an important trace element for many organisms and is incorporated into selenoproteins as selenocysteine (Sec). In eukaryotes, selenophosphate synthetase SPS2 is essential for Sec biosynthesis. In recent years, genetic disruptions of both Sec biosynthesis genes and selenoprotein gene...
ORGANISM(S): Drosophila melanogaster 
2016-04-06 | E-GEOD-79924 | biostudies-arrayexpress
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