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ProteomicsRiboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative damage is tightly buffered by glutathione peroxidase 4 (GPX4), and endogenous radical-trapping antioxidants such as ubiquinone, vitamin E and K. Deficiencies in these protective systems have been linked to the accumulation of phospholipid peroxidation and ferrop...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD061038 | Pride
Riboflavin Ferroptosis Fsp1 Cell death Vitamin b2 
GenomicsFSP1 and histone deacetylases suppress cancer persister cell ferroptosis
FSP1 and histone deacetylases suppress cancer persister cell ferroptosis
PRJNA1295369 | ENA
TranscriptomicsGene Expression Profiling of Fibroblasts in Actute Kidney Injury
Fibroblasts are present in every organ. While the role fibroblasts in chronic diseases such as fibrosis or tumor expression has been extensively explored, little is known about their physiological role. The kidney possesses a unique capacity to recover from even severe acute injury. We study molecul...
ORGANISM(S): Mus musculus 
2014-10-28 | E-GEOD-62732 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse wild type and Fibroblast specific protein 1 expressing liver
The aim of this study was to investigate FSP1 in human and experimental liver disease, and to characterize FSP1-positive cells. Results: FSP1-positive cells are increased in human and experimental liver diseases including liver cancer but do not synthesize type I collagen or express other classical ...
ORGANISM(S): Mus musculus 
2010-12-14 | E-MTAB-287 | biostudies-arrayexpress
GenomicsFSP1 reprograms hepatic lipid metabolism via SIRT1-mediated KU70 deacetylation: an LDLR-bypass atheroprotection
FSP1 reprograms hepatic lipid metabolism via SIRT1-mediated KU70 deacetylation: an LDLR-bypass atheroprotection
PRJNA1526153 | ENA
UnknownPhase separation of FSP1 promotes ferroptosis.
Not available
S-EPMC10338336 | biostudies-literature
GenomicsSingle-cell RNA-sequencing of bone marrow samples from Fsp1-Cre Col1a1flox/flox mice and WT mice
Single-cell RNA-sequencing of bone marrow samples from Fsp1-Cre Col1a1flox/flox mice and WT mice
PRJNA764216 | ENA
UnknownVitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis.
Not available
S-EPMC12340812 | biostudies-literature
UnknownTargeting FSP1 triggers ferroptosis in lung cancer.
Not available
S-EPMC12779550 | biostudies-literature
UnknownCocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1.
Not available
S-EPMC12146761 | biostudies-literature
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