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MetabolomicsRiboflavin produced in the vagina by lactobacilli as symbiotic factor

The human vaginal microbiome, particularly its symbiosis with lactobacilli, plays a key role in maintaining women’s health. While lactic acid-mediated pathogen exclusion is well known, broader metabolic functions of vaginal lactobacilli remain underexplored. In this study, we analyzed the vaginal...

2025-09-26 | MTBLS7389 | MetaboLights
MetabolomicsExplore changes of riboflavin metabolism in acute pancreatitis

Gut barrier dysfunction is critical in the pathogenesis of acute pancreatitis (AP), yet the underlying mechanisms remain unclear. Mucin 2 (MUC2), the primary component of the intestinal mucus layer, is essential for gut homeostasis and microbial eubiosis. This study aimed to elucidate the protec...

2025-09-11 | MTBLS12981 | MetaboLights
TranscriptomicsRiboflavin depletion impairs cell proliferation in intestinal cells: Identification of mechanisms and consequences
Microarray analysis has been applied to the cell proliferation in a human colonic cel line, Caco-2. We have shown previously that a moderate riboflavin depletion around weaning has a profound impact on the structure and function of the small intestine of the rat, which is not reversible following ri...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15132 | biostudies-arrayexpress
MetabolomicsGut Microbiota-Derived Riboflavin Mediates Protective Effects of MUC2 in Acute Pancreatitis via CD40-Macrophage Pathway

Gut barrier dysfunction is critical in the pathogenesis of acute pancreatitis (AP), yet the underlying mechanisms remain unclear. Mucin 2 (MUC2), the primary component of the intestinal mucus layer, is essential for gut homeostasis and microbial eubiosis. This study aimed to elucidate the protect...

2025-09-05 | MTBLS12943 | MetaboLights
TranscriptomicsTranscriptome profiles of a riboflavin-producing B.subtilis RH33 and wild type B.subtilis 168
The transcriptome profiles of a riboflavin-producing recombinant Bacillus subtilis RH33 and wild type Bacillus subtilis 168 were compared using DNA microarrays to identify the target genes for further enhancing riboflavin production. Transcriptome profiles of a riboflavin-producing B. subtilis RH33 ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2010-05-05 | E-GEOD-12873 | biostudies-arrayexpress
ProteomicsProteomics data for Mycobacterium tuberculosis mutants of the riboflavin biosynthetic pathway
Project Description This dataset contains raw DIA data for the proteome of wild-type and riboflavin biosynthetic pathway gene deletion mutants of Mycobacterium tuberculosis (Mtb). These strains were generated to investigate the essentiality of the riboflavin biosynthetic pathway, the source of metab...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Bacteria 
2025-12-15 | PXD068335 | Pride
Tuberculosis Mycobacteria Riboflavin Proteomics 
ProteomicsProteomics data for Mycolicibacterium smegmatis mutants of the riboflavin biosynthetic pathway
This dataset contains raw DIA data for the proteome of wild-type and riboflavin biosynthetic pathway gene deletion mutants of Mycolicibacterium smegmatis (Msm). These strains were generated to investigate the essentiality of the riboflavin biosynthetic pathway, the source of metabolic antigens recog...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-12-15 | PXD068360 | Pride
Tuberculosis Mycobacteria Riboflavin Smegmatis Proteomics 
ProteomicsRiboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative damage is tightly buffered by glutathione peroxidase 4 (GPX4), and endogenous radical-trapping antioxidants such as ubiquinone, vitamin E and K. Deficiencies in these protective systems have been linked to the accumulation of phospholipid peroxidation and ferrop...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD061038 | Pride
Riboflavin Ferroptosis Fsp1 Cell death Vitamin b2 
TranscriptomicsArabidopsis transcriptome changes caused by ectopic production of a turtle riboflavin-binding protein
Leaf contents of free riboflavin were modulated by ectopic expression of the turtle gene encoding riboflavin-binding protein (RfBP). Compared to Arabidopsis thaliana (L.) ecotype Col-0 (wild type), REAT (modified type) that constitutive express RfBP had 71%-77% less flavins of free form. We used mi...
ORGANISM(S): Arabidopsis thaliana 
2010-01-01 | E-GEOD-18417 | biostudies-arrayexpress
GenomicsAnaerobic riboflavin degradation by human gut Lachnospiraceae
Anaerobic riboflavin degradation by human gut Lachnospiraceae
PRJNA1422238 | ENA
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