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TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
TranscriptomicsZebrafish liver transcriptome in response to chronic treatment with environmentally relevant 5-FU
The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite that exerts its anticancer effects through inhibition of DNA synthesis and replication by inhibiting thymidylate synthase, and by incorporation of its metabolites into RNA and DNA. 5-FU is used in most of the currently applied regimens ...
ORGANISM(S): Danio rerio 
2015-04-23 | E-GEOD-63039 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of QUB HCT116 sensitive and resistant colorectal cancer time series
HCT116 parental, HCT116 5-FU resistant and HCT116 oxaliplatin resistant cells have been transiently treated with with their respective drug (5-FU or oxaliplatin) for 0, 6 12 or 24h in 3 independent experiments.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-390 | biostudies-arrayexpress
ProteomicsIMPRINTS-CETSA, 5-FU in parental and 5-FU-resistant HCT15 cells
Parental and 5-fluorouracil (5-FU)-resistant HCT15 cells were treated with 5-FU or vehicle for 12h and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobar...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026472 | JPOST Repository
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
Ibrutinib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005734 | Pride
Ibrutinib Activity-based protein profiling B-cell cancers Lc-ms/ms 
ProteomicsSSR4 deficiency in B-cell reshapes the inflammatory microenvironment
The development and differentiation of infiltrating B cells influence the structure of the immune microenvironment (TIME). We aimed to unveil the impact of regulating B cell development and antibodies secretion by glycosylation modification-associated protein SSR4 on the formation of IME structures ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD058527 | Pride
Mouse，b cells Ssr4 deficiency 
ProteomicsMCF7 xenografts with 5-FU in vivo ITDR-CETSA
MCF7 xenograft-bearing mice were treated intravenously for 22h with either vehicle or different 5-FU doses (10, 50, 100, and 150 mg/kg). Each xenograft was cut in similar-sized pieces and assembled into an ITDRCETSA scheme with 2 different heating temperatures (37ºC, 52ºC) and 3 xenograft pieces for...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026470 | JPOST Repository
TranscriptomicsSynergistic effects of 5-Fluorouracil in combination with Salinomycin promoted ferroptosis via inhibiting SLC7A11/GPX4 in Colorectal Cancer
Purpose: 5-FU resistance is considered to be a possible reason for the failure of conventional drug treatment of colorectal cancer (CRC). Recently, salinomycin (SAL), as a selective inhibitor of cancer stem cells (CSCs), has been used to sensitize and attenuate a variety of solid tumor chemotherapy ...
ORGANISM(S): Homo sapiens 
2025-06-21 | E-MTAB-15206 | biostudies-arrayexpress
ProteomicsIdentification of the target protein of the anticancer peptide Yaku’amide B
Yaku’amide B-binding proteins were enriched and purified from MCF-7 cell lysates using a biotinylated photoaffinity probe of Yaku’amide B through photoaffinity labeling (PAL) pull-down, and subsequently identified by mass spectrometry.
ORGANISM(S): Homo Sapiens (human) 
2026-03-12 | PXD062001 | JPOST Repository
ProteomicsMDA5 signaling in splenic B cells from imiquimod-induced lupus mouse model with proteomics study
Abstract Introduction Several environmental stimuli may influence lupus, especially viral infection. We utilize an imiquimod-induced lupus mouse model focusing on TLR7 pathway and use proteomics analysis to figure out the specific pathway related to viral infection and its related protein expression...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034855 | Pride
Mouse model B cell Imiquimod (imq) Proteomics Lupus Mda5 
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