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TranscriptomicsZebrafish liver transcriptome in response to chronic treatment with environmentally relevant 5-FU
The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite that exerts its anticancer effects through inhibition of DNA synthesis and replication by inhibiting thymidylate synthase, and by incorporation of its metabolites into RNA and DNA. 5-FU is used in most of the currently applied regimens ...
ORGANISM(S): Danio rerio 
2015-04-23 | E-GEOD-63039 | biostudies-arrayexpress
UnknownAnalysis of quality characteristics and key aroma compounds variation in different Ming pepper varieties during ripening process.
Not available
S-EPMC12807834 | biostudies-literature
UnknownNetwork pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.
Not available
S-EPMC9359200 | biostudies-literature
ProteomicsER-associated degradation of Eag1 potassium channels by the RING E3 ubiquitin ligase MKRN1: the presence of a dual ubiquitination system
Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K+ channel are associated with neurodevelopmental diseases, indicating an important role of Eag1 during brain development. A disease-causing Eag1 mutant channel is linked to defective protein stability that involves enhanced...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023984 | Pride
Ring e3 Mkrn1 
UnknownSecond-line 5-FU plus nanoliposomal irinotecan versus FOLFOX/XELOX in metastatic pancreatic cancer after gemcitabine-nab-paclitaxel failure: a propensity score-matched analysis.
Not available
S-EPMC12639605 | biostudies-literature
UnknownA Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer.
Not available
S-EPMC5884014 | biostudies-literature
UnknownThe Post-Cholecystectomy Gut Microbiota Follows a Time-Varying Change-A Pilot Study.
Not available
S-EPMC12744953 | biostudies-literature
TranscriptomicsIdentification of WRKY22 direct targets under submergence in Arabidopsis with ChIP
To identify direct targets of WRKY22, we created a transgenic Arabidopsis line that expresses a c-myc epitope-tagged WRKY22 and used ChIP followed by microarray hybridization (ChIP-chip) to screen for candidates and validate the in vivo protein-DNA interactions with ChIP followed by quantitative PCR...
ORGANISM(S): Arabidopsis thaliana 
2013-07-03 | E-GEOD-40138 | biostudies-arrayexpress
UnknownInterstitial lung disease in systemic sclerosis-a retrospective cross-sectional study in Taiwan.
Not available
S-EPMC12858559 | biostudies-literature
ProteomicsMouse Neuroblastoma Cells Proteome by LC-MS/MS
N2a cells were transfected with pCAGGS vector or pCAGGS-RABV-M (expressing rabies virus matrix protein) for 36 hours, cells were lysed for SDS-PAGE. The area where the proteins were located in the SDS-PAGE was scooped and cut into small pieces of about 1 mm3; the decolorization solution (15 mM K3Fe(...
ORGANISM(S): Mus Musculus 
2023-08-09 | PXD044493 |
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