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MetabolomicsMetabolic and transcriptional response of Arabidopsis thaliana wildtype and mutants to Phytophtora infestans
The oomycete P. infestans is the causal agent of late blight, the most devastating potato disease. In contrast to potato, A. thaliana is able to successfully prevent colonization of the pathogen due to a multi-layered nonhost resistance. Several mutants have been isolated which are impaired in penet...
2025-07-04 | MTBLS18 | MetaboLights
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD005903 | Pride
Deacetylase inhibitor Sirt1 Cancer cells Lysine acetylation Stoichiometry Proteomics 
ProteomicsMetaproteomics Analysis of Microbial Diversity of Human Saliva and Tongue Dorsum in Young Healthy Individuals
dataset for metaproteomics analysis to characterize of the composition of salivary and tongue microbial communities within healthy subjects in the range of age between 20-30 years
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-26 | MSV000084137 | MassIVE
Proteomics5-Nitroimidazole ethers boost anti-Helicobacter pylori activity via a dual mode of action and effectively eradicate infections in vivo
Metronidazole (Metro) represents the front line-drug against Helicobacter pylori infections, but despite its crucial role as an antibiotic, little is known about its exact mode of action (MoA). To unravel cellular protein targets, we here performed activity-based protein profiling (ABPP) with tailor...
ORGANISM(S): Helicobacter pylori 26695 
2026-04-13 | PXD051773 | Pride
Abpp Full proteome Helicobacter pylori Mode of action Nitroimidazoles Secretome Lc-ms/ms 
ProteomicsDual-targeting 5-nitroimidazole ethers eradicate H. pylori by induction of stress and disabling its adaptive response
Metronidazole represents a front line-drug against Helicobacter pylori. To unravel its largely unknown cellular targets, we performed activity-based protein profiling (ABPP). Surprisingly, an alkynylated ether probe (Metro-P3) exhibited a 60-fold enhanced potency. Chaperonin HpGroEL and thiol peroxi...
ORGANISM(S): Staphylococcus pseudintermedius Staphylococcus schleiferi 
2026-04-13 | PXD067473 | Pride
Abpp Lc-msms Bacteria 
ProteomicsThe permanently chaperone-active small heat shock protein Hsp17 from C. elegans exhibits topological separation of its N-terminal regions
Small Heat shock proteins (sHsps) are a family of molecular chaperones that bind non-native proteins in an ATP-independent manner. C. elegans encodes 16 different sHsps, among them Hsp17, which is evolutionarily distinct from other sHsps in the nematode. The structure and mechanism of Hsp17 and how ...
ORGANISM(S): Caenorhabditis elegans 
2022-12-08 | PXD038019 | Pride
Molecular chaperone Protein structure Protein aggregation Small heat shock protein 
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella <scale Insect> (ncbitaxon:108061) Morganella <fungus> (ncbitaxon:90690) Pseudomonas Sp. (ncbitaxon:306) Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079927 | MassIVE
UnknownSpread of Terbinafine-Resistant Trichophyton mentagrophytes Type VIII (India) in Germany-"The Tip of the Iceberg?"
Not available
S-EPMC7712673 | biostudies-literature
ProteomicsCritical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows
Metaproteomics, the study of the collective proteome within a microbial ecosystem, has substantially grown over the past few years. This growth comes from the increased awareness that it can powerfully supplement metagenomics and metatranscriptomics analyses. Although metaproteomics is more challeng...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089620 | MassIVE
TranscriptomicsParthenogenetic stem cells for tissue-engineered heart repair
Uniparental parthenotes are considered an unwanted byproduct of in vitro fertilization. In utero parthenote development is severely compromised by defective organogenesis and in particular by defective cardiogenesis. Although developmentally compromised, apparently pluripotent stem cells can be deri...
ORGANISM(S): Mus musculus 
2013-02-23 | E-GEOD-30868 | biostudies-arrayexpress
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