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MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
TranscriptomicsTranscriptional profiles of NCTC11168 grown with or without 25mM fucose
Strain specific growth of C. jejuni on fucose has been linked to a plasticity region of the chromosome (PR2) and confers a competitive advantage during intestinal colonization. Growth on fucose induces gene expression of PR2 genes, but the regulatory mechanism of the structural genes involved with ...
ORGANISM(S): Campylobacter jejuni 
2014-01-01 | E-GEOD-46752 | biostudies-arrayexpress
TranscriptomicsCampylobacter jejuni Utilization of Fucose
Transcriptional profile of C. jejuni NCTC11168 while growing in MEM medium containing L-fucose. We hypothesize that certain C. jejuni strains, containing A certain genomic island, have acquired the ability to metabolize fucose. This study demonstrates the transcriptional profile C. jejuni growth w...
ORGANISM(S): Campylobacter jejuni 
2011-04-01 | E-GEOD-28294 | biostudies-arrayexpress
MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
TranscriptomicsTranscriptional profiles of wild-type NCTC11168 and Cj0480c mutant grown without fucose
Strain specific growth of C. jejuni on fucose has been linked to a plasticity region of the chromosome (PR2) and confers a competitive advantage during intestinal colonization. Growth on fucose induces gene expression of PR2 genes, but the regulatory mechanism of the structural genes involved with ...
ORGANISM(S): Campylobacter jejuni 
2014-01-01 | E-GEOD-46808 | biostudies-arrayexpress
ProteomicsGlycoproteomic analysis of fucose-containing proteins in small intestine identified cryptdin-related sequence 1 as O-glycosylated proteins modified with α1,2-fucose
The modification of galactose with α1,2-fucose is involved in symbiosis with intestinal bacteria and elimination of pathogenic bacteria. It is postulated that α1,2-fucosylated mucin secreted from goblet cells is involved in defending an organism against infections, but the detailed molecular mechani...
ORGANISM(S): Mus Musculus (mouse) 
2020-11-05 | PXD022132 | JPOST Repository
ProteomicsImproving the Accuracy and Efficiency of Core Fucose Identification Using Machine Learning
In this study, we employed artificial intelligence to address the challenges in identifying core fucose due to migration effects. By knocking out the FUT8 gene in normal mouse brains, we ensured accurate labeling of non-core fucosylated glycans, enabling the identification of mannose glycans with co...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD062880 | Pride
Core fucose Mouse brain Intact glycopeptides Fut8 knockout 
ProteomicsO-Fucose glycans on mouse NOTCH1 from activated T cells of Fringe mutant mice
NOTCH1 (N1) is a transmembrane receptor that initiates a cell-cell signaling pathway controlling various cell fate specifications in metazoans. The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD031297 | Pride
T cell Notch1 O-fucose Fringe Pofut1 
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