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TranscriptomicsNovel kinase fusion oncogenes in post-Chernobyl radiation-induced pediatric thyroid cancers
Exposure to ionizing radiation during childhood markedly increases the risk of developing papillary thyroid cancer. We identified non-overlapping somatic driver mutations in all 26 cases of post-Chernobyl thyroid cancers we studied through candidate gene assays and next generation RNA-sequencing. We...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-48850 | biostudies-arrayexpress
TranscriptomicsIn Vitro Transformation of Primary Human CD34+ Cells by AML Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target in AML
Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation. Here we compare the in vitro effects of representatives of major groups of AML fusion oncogenes on primary human CD34+ cells. For the 3 d ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-57194 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq reveals activation of unique gene groups as a consequence of stem cell-parenchymal cell fusion
Fusion of donor mesenchymal stem cells with parenchymal cells of the recipient can occur in the brain, liver, intestine and heart following transplantation. The therapeutic benefit or detriment of resultant hybrids is unknown. Here we sought a global view of phenotypic diversification of mesenchym...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69926 | biostudies-arrayexpress
ProteomicsProbing downstream effects of ALK and ROS1 fusion oncogenes in Glioma using proteomics
To identify targets of aberrantly expressed RTK-fusion oncogenes, serine/threonine and tyrosine phosphorylation signatures in transgenic cells lines expressing different RTK-fusion oncogenes were compared with their respective kinasedead mutant counterparts. Comparing the differentially phosphorylat...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD059984 | Pride
Alk Ap-ms Ros1 Immortalized normal human astrocytes Phosphoprotoemics Rtk-fusion oncoproteins 
ProteomicsALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression
Anaplastic lymphoma kinase (ALK) fusion variants in non-small-cell-lung cancer (NSCLC) consist of numerous dimerising fusion partners, with the most common being EML4. Clinical data suggests that the degree of treatment benefit in response to ALK tyrosine kinase inhibitors (TKIs) differs among the v...
ORGANISM(S): Homo sapiens (Human) 
2023-02-16 | PXD035100 | Pride
Human Nsclcl Orbitrap fusion lumos 
UnknownClinically relevant fusion oncogenes: detection and practical implications.
Not available
S-EPMC9806411 | biostudies-literature
GenomicsSRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors [C2C12]
SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors [C2C12]
PRJNA1294619 | ENA
GenomicsSRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors [MSC_hTERT]
SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors [MSC_hTERT]
PRJNA1294620 | ENA
TranscriptomicsOntogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia - scRNAseq - 2
Paediatric cancers present specific genetic alterations, however the principles underlying their differences to adult cancers are yet unclear. Poor prognosis paediatric myeloid leukaemia fusion oncogenes represent clinically-relevant models to investigate age-specific tumorigenesis. Here, we establi...
ORGANISM(S): Mus musculus 
2019-10-15 | E-MTAB-8360 | biostudies-arrayexpress
UnknownIdentification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.
Not available
S-EPMC3809792 | biostudies-literature
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