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MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
MetabolomicsA metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis
Not available
ORGANISM(S): Homo sapiens 
ST002234 | MetabolomicsWorkbench
MetabolomicsDefective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in liver
Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. CO...
2024-07-19 | MTBLS9823 | MetaboLights
TranscriptomicsGene expression data from Arabidopsis C24 wild-type and ros1-1 seedlings.
We carried out a microarray experiment by using Affymetrix Arabidopsis ATH1 Genechips in order to identify genes that show reduced expression in ros1-1 plants. 2 samples examined: C24 wild-type and ros1-1 mutant (in C24 background).
ORGANISM(S): Arabidopsis thaliana 
2013-11-23 | E-GEOD-52669 | biostudies-arrayexpress
GenomicsThe WOPR protein Ros1 is a master regulator of sporogenesis and effector gene expression in the maize pathogen Ustilago maydis [ChIP-Seq]
Goals: characterization of the transcription factor Ros1 in Ustilago maydis Methods: generation of deletion mutants, microscopic observations, ectopic expression of ros1, identification of Ros1 regulated genes by RNAseq and ChIP sequencing Results: Ros1 is not involved in plant colonization but is ...
ORGANISM(S): Ustilago maydis 
2016-06-24 | E-GEOD-76230 | biostudies-arrayexpress
ProteomicsDifferential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology: Phosphoproteomics
Multiple tyrosine kinase inhibitors (TKIs) are often developed for the same indication. However, their relative overall efficacy is frequently incompletely understood and they may harbor unrecognized targets that cooperate with the intended target. We compared several ROS1 TKIs for inhibition of ROS...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD031359 | Pride
Polypharmacology Tyrosine kinase inhibitors Phosphoproteomics Ros1 Lung cancer Lorlatinib 
ProteomicsDifferential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology: Phosphotyrosine Profiling
Multiple tyrosine kinase inhibitors (TKIs) are often developed for the same indication. However, their relative overall efficacy is frequently incompletely understood and they may harbor unrecognized targets that cooperate with the intended target. We compared several ROS1 TKIs for inhibition of ROS...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD031346 | Pride
Polypharmacology Tyrosine kinase inhibitors Phosphotyrosine Ros1 Lung cancer Lorlatinib 
GenomicsWhole genome bisulfite sequencing of rdm16ros1, ros1, nrpd1ros1 mutants and C24 wild-type
Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in rdm16ros1, ros1, nrpd1ros1 mutants and examine the effect of RDM16 on DNA methylation 4 samples examined: C24 wild type with RD29A-LUC transgene, rdm16ros1 double mutant, ros1 mutant, nrpd1ros1 mut...
ORGANISM(S): Arabidopsis thaliana 
2013-09-27 | E-GEOD-44417 | biostudies-arrayexpress
TranscriptomicsExperiment comparing transcriptomes of red and purple tissue sections on Del/Ros1 Moneymaker fruit
Microarray analysis was used to compare the gene expression profiles of red and purple sectors of VIGS (Virus-induced gene silencing)-treated Del/Ros1 fruit in the MoneyMaker background. Fruit were silenced at the mature green stage and harvested at differing number of days after breaker. Custom two...
ORGANISM(S): Solanum lycopersicum 
2013-05-06 | E-GEOD-46341 | biostudies-arrayexpress
ProteomicsDifferential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology: Chemical Proteomics
Multiple tyrosine kinase inhibitors (TKIs) are often developed for the same indication. However, their relative overall efficacy is frequently incompletely understood and they may harbor unrecognized targets that cooperate with the intended target. We compared several ROS1 TKIs for inhibition of ROS...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD031690 | Pride
Polypharmacology Tyrosine kinase inhibitors Chemical proteomics Ros1 Lung cancer Lorlatinib 
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