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ProteomicsAnalysis of the impact of DICER1 and DROSHA on the angio-genic capacity of human endothelial cells
RNAi-mediated knockdown of DICER1 and DROSHA, enzymes critically involved in miRNA biogenesis, has been postulated to affect the homeostasis and the angiogenic capacity of human endothelial cells. To re-evaluate this issue, we reduced the expression of DICER1 or DROSHA by RNAi-mediated knockdown and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027923 | Pride
Endothelial cells  angiogenesis  microrna biogenesis Dicer1  drosha  rna interference 
ProteomicsDisturbance of key cellular subproteomes upon propofol treatment is associated with increased permeability of the blood-brain barrier
Background: Propofol is a short-acting anesthetic, which is often used for induction and maintenance of general anesthesia, sedation for mechanically ventilated adults and procedural sedation. Several side effects of propofol are known and a substantial number of patients suffer from post-operative ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD033856 | Pride
Anesthetics  blood-brain barrier  dna damage response  drug effect  human brain microvascular endothelial cells  metabolic stress  propofol  proteome  quantitative proteomics  reactive oxygen species (ros) 
ProteomicsLinking the transcriptome to physiology: response of the proteome of Cupriavidus metallidurans to changing metal availability
Cupriavidus metallidurans CH34 is a metal-resistant bacterium. Its metal homeostasis is based on a flow equilibrium of metal ion uptake and efflux reactions, which adapts to changing metal concentrations within an hour. At high metal concentrations, up-regulation of the genes for metal efflux system...
ORGANISM(S): Cupriavidus metallidurans CH34 Bacteria 
2025-05-07 | PXD057750 | Pride
Cupriavidus metallidurans Proteomics Transenvelope efflux systems Zinc Metal starvation Metal homeostasis 
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