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Fzd6 knockout skin E15.5
Frizzleds (FZD) function as receptors for secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, initiating an important signal transduction network in multicellular organisms. FZDs are classified as G protein-coupled receptors (GPCRs), which control a wide variety of physiological functions...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD011173 | Pride
RNA sequencing of FZD6 knockdown in prostate cancer cells
The hair follicle misorientation phenotype in Fzd6-/- mice appears to act through the PCP signaling system, but the downstream effectors of Fzd6 remain mysterious. We used microarrays to search for potential downstream effectors of the Fzd6 signaling pathway in regulating hair follicle orientation.
ORGANISM(S): Mus musculus 
2018-09-14 | GSE119928 | GEO
Wnt signaling is a complex pathway consisting of numerous ligands and frizzled (FZD) receptors. These signaling components are widely expressed in human prostate tissues and often undergo upregulation or mutation in advanced prostate cancers. Enhanced Wnt signaling promotes prostate cancer cell prol...
ORGANISM(S): Homo sapiens 
2025-12-10 | GSE276026 | GEO
Nails protect the soft tissue of the tips of digits in humans. In birds and mammals the equivalent claws are used for purposes including capturing prey, digging, climbing, fighting and maintaining dexterity and balance. The molecular mechanism of nail (and claw) development is largely unknown, but w...
ORGANISM(S): Mus musculus 
Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Alveolar Cell Death induced by LPS and Corona Virus [RNA-seq subset I]
Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Alveolar Cell Death induced by LPS and Corona Virus [RNA-seq subset II]
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