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UnknownRegulation of DEAH/RHA helicases by G-patch proteins.
Not available
S-EPMC4322301 | biostudies-literature
UnknownInvolvement of G-patch domain containing 2 overexpression in breast carcinogenesis.
Not available
S-EPMC11158124 | biostudies-literature
UnknownStructural basis for DEAH-helicase activation by G-patch proteins.
Not available
S-EPMC7132122 | biostudies-literature
UnknownG-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.
Not available
S-EPMC3179746 | biostudies-literature
ProteomicsGPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, but therapeutic means to correct this mis-splicing do not exist. Here, we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD051128 | Pride
Sf3b1 Sugp1 Splicing Dhx15 Gpatch8 Leukemia Myelodysplastic syndromes Rna G-patch domain 
ProteomicsGPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, but therapeutic means to correct this mis-splicing do not exist. Here, we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD044973 | Pride
Sugp1. Sf3b1 Splicing Dhx15 Gpatch8 Leukemia Myelodysplastic syndromes Rna G-patch domain 
UnknownThe G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
Not available
S-EPMC7971346 | biostudies-literature
ProteomicsProteomic analysis of Mason-Pfizer monkey virus virions
To accomplish their replication cycle, retroviruses rely heavily on a wide variety of cellular proteins and enzymes, such as helicases. Among these, the DExD-box and DEAH/RHA-box helicases were identified to play crucial roles in their nucleic acid metabolism. This study explores the Betaretrovirus ...
ORGANISM(S): Mason-Pfizer monkey virus 
2024-09-13 | PXD046672 | Pride
Mason-pfizer monkey virus Dhx15 G-patch domain Hek 293 Lc-ms/ms 
ProteomicsGPATCH11 ortholog Sap34 regulates pre-mRNA splicing by interacting with early spliceosomal complexes in Schizosaccharomyces pombe
Pre-mRNA splicing is an essential step in gene expression regulation. It is mediated by the spliceosome, a large ribonucleoprotein complex that undergoes dynamic structural and compositional rearrangements during each splicing cycle. Although the mechanisms of splicing and the roles of main spliceos...
ORGANISM(S): Schizosaccharomyces pombe 927 
2026-04-21 | PXD077306 | Pride
G-patch protein  sap34  spac6f6.19  splicing factor  pre-mrna splicing  fission yeast 
UnknownRegulation of the DEAH/RHA helicase Prp43 by the G-patch factor Pfa1.
Not available
S-EPMC9860317 | biostudies-literature
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