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ProteomicsGPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, but therapeutic means to correct this mis-splicing do not exist. Here, we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD044973 | Pride
Sugp1. Sf3b1 Splicing Dhx15 Gpatch8 Leukemia Myelodysplastic syndromes Rna G-patch domain 
UnknownGPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies.
Not available
S-EPMC11102302 | biostudies-literature
ProteomicsGPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, but therapeutic means to correct this mis-splicing do not exist. Here, we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD051128 | Pride
Sf3b1 Sugp1 Splicing Dhx15 Gpatch8 Leukemia Myelodysplastic syndromes Rna G-patch domain 
GenomicsSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [TRIBE-seq]
Synthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [TRIBE-seq]
PRJNA1011321 | ENA
GenomicsSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-seq]
Synthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-seq]
PRJNA1011320 | ENA
GenomicsSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-Seq 2]
Synthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-Seq 2]
PRJNA1090048 | ENA
OtherSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [TRIBE-seq]
Mutations in the RNA splicing factor SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing but therapeutic means to correct this mis-splicing do not exist. Here we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans factors...
ORGANISM(S): Homo sapiens 
2023-09-01 | GSE242093 | GEO
TranscriptomicsSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-seq]
Mutations in the RNA splicing factor SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing but therapeutic means to correct this mis-splicing do not exist. Here we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans factors...
ORGANISM(S): Homo sapiens 
2023-09-01 | GSE242092 | GEO
TranscriptomicsSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations [RNA-Seq 2]
Mutations in the RNA splicing factor SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing but therapeutic means to correct this mis-splicing do not exist. Here we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans factors...
ORGANISM(S): Homo sapiens 
2024-03-20 | GSE262021 | GEO
GenomicsSynthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations
Synthetic Introns Identify GPATCH8 as Required for Mis-splicing by SF3B1 Mutations
PRJNA1011318 | ENA
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